Effects of carnitine supplementation on muscle metabolism by the use of magnetic resonance spectroscopy and near-infrared spectroscopy in end-stage renal disease

Nephron. Clinical Practice
E C VauxP Styles

Abstract

A defect in skeletal muscle mitochondrial metabolism develops in patients with chronic renal failure on haemodialysis. Treatment with carnitine, a compound essential for normal mitochondrial function, has been suggested to have significant benefits in such patients, so we carried out a study to see if carnitine acts by improving muscle bioenergetics and function. In a phase II randomised double-blind trial, patients with end-stage renal disease received placebo or intravenous L-carnitine (20 mg/kg dry body weight three times weekly after haemodialysis) for 16 weeks (n = 13 in each group). 31P magnetic resonance spectroscopy, 1H magnetic resonance imaging and near-infrared spectroscopy were used to measure muscle bioenergetics and function at baseline and at 16 weeks. There were no significant differences between groups at baseline. Mean plasma carnitine rose 10-fold in the carnitine group but was unchanged in the placebo group. L-carnitine had no statistically significant effect on any of the parameters measured. The rate of proton efflux from muscle, as a measure of tissue perfusion, was low in both groups and was not affected by treatment. The study failed to show any significant effect of 16 weeks' L-carnitine supplementatio...Continue Reading

Citations

Sep 30, 2005·Hemodialysis International·Jeffrey S Berns, Ari Mosenkis
Sep 26, 2008·Kidney International. Supplement·Scott W KlarenbachUNKNOWN Canadian Society of Nephrology
Aug 19, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine E LynchSteven M Brunelli
Jan 3, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Gianfranco GuarnieriRocco Barazzoni
Jun 22, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Bojan KnapAndrej F Bren
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Dec 5, 2017·The Tohoku Journal of Experimental Medicine·Sergej M Ostojic
Jul 9, 2008·Current Sports Medicine Reports·William J KraemerCourtenay Dunn-Lewis
Mar 29, 2021·European Journal of Clinical Investigation·Marieta P TheodorakopoulouPantelis Sarafidis
May 1, 2021·Nutrients·Hiroyuki TakashimaMasanori Abe
Mar 14, 2021·International Urology and Nephrology·Yan ZhuJin Deng

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