Effects of carprofen and morphine on the minimum alveolar concentration of isoflurane in dogs

Journal of the American Animal Hospital Association
Jeff C H KoTomohito Inoue

Abstract

The minimum alveolar concentration (MAC) of isoflurane in dogs was determined following carprofen (2.2 mg/kg per os) alone, morphine (1 mg/kg intravenously) alone, carprofen and morphine, and no drug control in eight healthy adult dogs. Isoflurane MAC following administration of morphine alone (0.81%+/-0.18%) or carprofen and morphine (0.68%+/-0.31%) was significantly less than the control MAC (1.24%+/-0.15%). Isoflurane MAC after carprofen alone (1.13%+/-0.13%) was not significantly different from the control value. Results indicated that administration of morphine alone or in combination with carprofen significantly reduced the MAC of isoflurane in dogs. The isoflurane MAC reduction was additive between the effects of carprofen and morphine.

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Citations

Apr 17, 2015·Veterinary Anaesthesia and Analgesia·Eduardo R MonteiroBetânia S Monteiro
Sep 22, 2012·Veterinary Anaesthesia and Analgesia·Vilhelmiina HuuskonenEleanor West
Apr 16, 2011·Veterinary Anaesthesia and Analgesia·Pedro BoscanEugene P Steffey
Oct 24, 2019·American Journal of Veterinary Research·Brittney A JohnsonMary A McLoughlin
Aug 11, 2017·Animals : an Open Access Journal From MDPI·Heidi S LehmannGabrielle C Musk

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