Effects of Carvedilol Versus Metoprolol on Platelet Aggregation in Patients With Acute Coronary Syndrome: The PLATE-BLOCK Study

The American Journal of Cardiology
Federica IlardiGiovanni Esposito

Abstract

Platelet aggregation plays a pivotal role in acute coronary syndrome (ACS). In this setting, β-blockers (BBs) are used to counteract the effects of catecholamines on heart. Circulating catecholamines can also potentiate platelet reactivity, mainly through α2- and β2-adrenoceptors on human platelets' surface, thus BB may affect platelet aggregation; however, the effects of different BBs on platelet aggregation in contemporary-treated patients with ACS have been poorly investigated. One hundred patients with ACS on dual antiplatelet therapy with aspirin and ticagrelor were randomized to receive treatment with carvedilol, a nonselective BB (n = 50), or metoprolol, a selective β1-blocker (n = 50), at maximum tolerated dose. Light transmission aggregometry was performed at randomization (T0) and at 30-day follow-up (T30), and the results were expressed as a percentage of maximum platelet aggregation (MPA). The primary end point was epinephrine-induced MPA at 30 days. Patients were predominantly men (80%), and mean age was 57.3 ± 9.7 years. The 2 randomized groups were well balanced for baseline characteristics. At T0, mean MPA was similar between the groups (18.96 ± 9.05 vs 18.32 ± 9.21 with 10 µM epinephrine, 14.42 ± 9.43 vs 15.98 ...Continue Reading

Citations

Jun 11, 2020·Journal of Cardiovascular Medicine·Federica IlardiGiovanni Esposito
Nov 28, 2018·Immunity & Ageing : I & a·Roberta EspositoValentina Trimarco
Aug 14, 2018·European Journal of Clinical Investigation·Christopher AdlbrechtAlberto Bouzas-Mosquera
Oct 24, 2020·The Nurse Practitioner·Mohamed El Hussein, Jonah Hakkola
Nov 25, 2020·International Journal of Molecular Sciences·Chih-Fan YehWei-Kai Wu
Feb 24, 2021·The American Journal of Cardiology·Ghaith ZaatariUNKNOWN Outcomes of Beta-blocker Therapy After myocardial INfarction (OBTAIN) Investigators
Apr 4, 2021·Toxins·Justyna Fryc, Beata Naumnik
May 19, 2021·The Nurse Practitioner·Mohamed Toufic El Hussein, Jonah Hakkola

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