Effects of Cataract Surgery on Melatonin Secretion in Adults 60 Years and Older: A Randomized Clinical Trial

JAMA Ophthalmology
Tomo NishiNahoko Ogata

Abstract

Cataract surgery, which increases perception of light, may increase melatonin secretion. Melatonin secretion has been associated with depression, diabetes, cognitive impairment, and breast cancer. To date, no evidence from a randomized clinical trial exists to support this cataract surgery hypothesis. To determine whether cataract surgery modifies the melatonin secretion at 3 months after cataract surgery in 169 adult patients. A parallel-group randomized clinical trial was conducted at a single referral center from July 1, 2014, to June 30, 2017. Data were analyzed from January 1, 2018, to March 31, 2019. Patients were aged 60 years or older, had no history of cataract surgery, and had cataracts with grade 2 or higher nuclear opacifications based on the Lens Opacities Classification System III. Analyses were based on intention to treat. Patients were randomized 1:1:1:1 to receive cataract surgery using artificial clear intraocular lens (IOL) or yellow IOL. Group 1 received prompt surgery with clear IOL, group 2, prompt surgery with yellow IOL, group 3, delayed surgery with clear IOL, and group 4, delayed surgery with yellow IOL. The intervention group consisted of groups 1 and 2, and the control group consisted of groups 3 and...Continue Reading

References

Jun 1, 1983·Archives of Ophthalmology·D R SandersM C Kraff
Apr 30, 2003·The Journal of Physiology·Sat Bir S KhalsaCharles A Czeisler
Apr 20, 2004·Journal of Cataract and Refractive Surgery·Janet R SparrowJilin Zhou
Jul 8, 2005·Scandinavian Journal of Work, Environment & Health·Yuko MorikawaKoji Nogawa
Feb 1, 2006·Acta Ophthalmologica Scandinavica·Peep V AlgvereStefan Seregard
May 19, 2006·American Journal of Epidemiology·Yoshihisa FujinoUNKNOWN Japanese Collaborative Cohort Study Group
Jun 12, 2008·Journal of the National Cancer Institute·Eva S SchernhammerPaola Muti
Sep 2, 2008·The British Journal of Ophthalmology·P L Turner, M A Mainster
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eva S Schernhammer, Susan E Hankinson
Apr 10, 2009·American Journal of Epidemiology·Devin L BrownLynda D Lisabeth
Aug 19, 2009·Scandinavian Journal of Work, Environment & Health·Ana-Claudia Bara, Sara Arber
Sep 10, 2009·Occupational and Environmental Medicine·A PietroiustiA Magrini
Jan 9, 2010·Sleep Medicine Reviews·Patricia L TurnerMartin A Mainster
Feb 16, 2010·Journal of Cataract and Refractive Surgery·Line KesselMichael Larsen
Dec 3, 2011·The British Journal of Ophthalmology·Donatella Pascolini, Silvio Paolo Mariotti
Jun 26, 2012·Journal of Pineal Research·José L MaurizJavier González-Gallego
Jul 28, 2012·BMJ : British Medical Journal·Manav V VyasDaniel G Hackam
Sep 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Kenji ObayashiNorio Kurumatani
Jan 25, 2013·Occupational and Environmental Medicine·Elisabeth FloBjørn Bjorvatn
Apr 4, 2013·JAMA : the Journal of the American Medical Association·Ciaran J McMullanJohn P Forman
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Kenji ObayashiNorio Kurumatani
Jun 9, 2015·The Journal of Clinical Endocrinology and Metabolism·Kenji ObayashiNorio Kurumatani
Mar 5, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenji ObayashiNorio Kurumatani
Jul 8, 2016·Chronobiology International·Yan ShenshenWang Wei
May 23, 2018·The Cochrane Database of Systematic Reviews·Laura E DowniePeter R Keller

❮ Previous
Next ❯

Citations

Aug 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arezoo Fathalizadeh AlamdariSarvin Sanaie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.