PMID: 9175615Mar 1, 1997Paper

Effects of catechol-O-methyltransferase inhibition on the rates of uptake and reversibility of 6-fluoro-L-Dopa trapping in MPTP-induced parkinsonism in monkeys

Neuropharmacology
D J DoudetT J Ruth

Abstract

The uptake rate constant and the loss rate constant that expresses the reversibility of the uptake process of 6-[18F]fluoro-L-Dopa (FDOPA) were measured by positron emission tomography in the striatum of normal rhesus monkeys and in monkeys with unilateral lesions of the dopaminergic nigro-striatal pathway, induced by intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Each animal was studied twice: with and without pretreatment of the catechol-O-methyltransferase (COMT) inhibitor Ro 40-7592, tolcapone. After pretreatment with tolcapone, there was a very significant increase in plasma FDOPA throughout the course of the study, accompanied by a significant decrease in its main metabolite, 3-O-methylfluorodopa. Tolcapone did not induce a significant change in the uptake rate constant in either the normal or the MPTP-treated striatum. However, after tolcapone pretreatment, there was a significant decrease in the loss rate constant in the MPTP-treated striatum (25%) and a smaller, non-significant decrease in the normal striatum (13%). It is concluded that the COMT inhibitor tolcapone exhibits clear peripheral and central activity. As compared to peripheral COMT inhibitors, this central effect may help pres...Continue Reading

References

Aug 1, 1992·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·M NamavariJ R Barrio
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C A McLellanR M Cohen
Jan 1, 1991·Journal of Neural Transmission. General Section·J TedroffB Långström
Jan 1, 1990·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·J MajJ Superata
Oct 1, 1989·Annals of Neurology·W R MartinD B Calne
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S Patlak, R G Blasberg
Jan 1, 1993·Journal of Neural Transplantation & Plasticity·D J DoudetR M Cohen
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T IshikawaD Eidelberg
Jun 1, 1994·Clinical Neuropharmacology·J M GarridoJ G de Yébenes
Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H M RuottinenU K Rinne

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Citations

Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J DoudetJ E Holden
Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshitaka KumakuraPaul Cumming
Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthew D WalkerVesna Sossi
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·A Jon StoesslDavid Eidelberg
Dec 17, 2014·Brain Imaging and Behavior·Catherine L GallagherJames E Holden
Aug 5, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshitaka KumakuraPaul Cumming
Aug 22, 2006·JAAPA : Official Journal of the American Academy of Physician Assistants·Sharon S Moser, Wendy Besler-Panos
Jul 22, 2018·Psychopharmacology·Jennifer M MitchellAndrew S Kayser

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