PMID: 20626142Jul 16, 2010Paper

Effects of catgut embedding at "Shimen" (CV 5) on the endometrial receptivity during the periimplantation period in mice

Zhen ci yan jiu = Acupuncture research
Ou ZhangLi-yan Zheng

Abstract

To observe the effect of catgut embedding (CE) at "Shimen" (CV 5) on the endometrial receptivity, pinopodes expression of the endometrial surface and leukaemia inhibitory factor (LIF) immunoactivity during periimplantation period. Thirty Kunming mice were randomly divided into control, CE of "Shimen" (CV 5, CE-CV 5) and medication groups (n = 10/group). For mice of CE-CV 5 group, a piece of catgut was embedded into the subcutaneous tissue of "Shimen" (CV 5) on the day when the vagina-discharged epistom was found (pregnancy day 1, Pd 1). On Pd 4, mifepristone (0.1 mL, diluted in propylene glycol) was subcutaneously injected into CV 5 in rats of medication group. The expression of endometrial pinopodes (sampled on Pd 5) was observed by scanning electron microscopy. The immunoactivity of LIF of the endometrium was detected by immunohistochemistry. Compared with control group, the mean optical density (OD) values of LIF in CE-CV 5 and medication groups decreased significantly (P < 0.05), suggesting an downregulation of the endometrial LIF expression. No significant difference was found between CE-CV 5 and medication group in LIF expression (P > 0.05). Electronic microscopic observation showed (1) abundant mature pinopodes on the en...Continue Reading

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