Effects of CCK-tetrapeptide in patients with social phobia and obsessive-compulsive disorder

Depression and Anxiety
Martin A KatzmanJacques Bradwejn

Abstract

Panicogenic sensitivity to CCK-tetrapeptide (CCK-4) is enhanced in panic disorder patients relative to normal controls (NC). We sought to determine whether CCK-4 sensitivity is augmented in patients with social phobia (SP) (n = 12) and obsessive-compulsive disorder (OCD) (n = 8) versus NC (n = 12). We also determined whether CCK-4 could elicit syndrome-specific symptoms in SP and OCD patients. The study employed a single-blind, placebo-controlled, within-subject design. Behavioral, cardiovascular and hormonal responses to a submaximal dose (20 microg) of CCK-4 were evaluated. Panic frequency after the placebo and CCK-4 challenge varied as a function of diagnosis. Differences in panic frequency between groups and between challenge agents within each group did not, however, reach statistical significance. Further, the number and intensity of panic symptoms, intensity of subjective anxiety, autonomic reactivity and hormonal release after CCK-4 administration did not distinguish the groups. Core symptoms of SP and OCD were unaffected by CCK-4. These data failed to detect significant differences between groups on behavioral, cardiovascular and hormonal response to CCK-4. The lack of effect of CCK-4 on SP and OCD symptoms suggests th...Continue Reading

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Citations

Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Qian ChenYa-Ping Tang
May 4, 2012·Depression and Anxiety·P ZwanzgerJ Bradwejn
Jul 16, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Riederer
Apr 17, 2020·Frontiers in Cellular Neuroscience·Xin-Rui Qi, Li Zhang
Aug 23, 2020·Brain Sciences·Matteo VismaraBernardo Dell'Osso

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