Effects of central airway shunting on the mechanical impedance of the mouse lung

Annals of Biomedical Engineering
Benjamin L SchwartzJason H T Bates

Abstract

The mechanical properties of the lung are embodied in its mechanical input impedance, which it is interpreted in physiological terms by being fit with a mathematical model. The normal lung is extremely well described by a model consisting of a single uniformly ventilated compartment comprised of tissue having a constant-phase impedance, but to describe the abnormal lung it frequently becomes necessary to invoke additional compartments. To date, all evidence of regional mechanical heterogeneity in the mouse lung has been assumed to be of the parallel variety. We therefore investigated the use of a serial heterogeneity model, relative to parallel heterogeneity and homogeneous models, for describing impedance spectra in mice subjected to a variety of interventions designed to make their lungs heterogeneous. We found that functional evidence of the finite stiffness of the airway wall in mice with airways obstruction can sometimes be apparent in lung impedance below 20 Hz. The model estimates of airway stiffness were smaller than direct estimates obtained from micro-CT images of the lung in vivo, suggesting that the conducting airways alone are likely not the precise anatomical correlate of proximal functional stiffness in the lung....Continue Reading

References

Jan 1, 1992·Journal of Applied Physiology·Z HantosJ J Fredberg
Sep 1, 1995·IEEE Transactions on Bio-medical Engineering·T F Schuessler, J H Bates
Jan 1, 1997·Journal of Applied Physiology·J H BatesD H Eidelman
May 1, 1997·Journal of Applied Physiology·D W KaczkaK R Lutchen
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·D W KaczkaK R Lutchen
Jan 14, 1999·Journal of Applied Physiology·T HiraiJ H Bates
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·A DuguetD H Eidelman
Aug 24, 2000·Journal of Applied Physiology·R F GomesJ H Bates
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·K R LutchenE P Ingenito
Jun 19, 2002·Journal of Applied Physiology·Shinichiro TomiokaCharles G Irvin
Jul 3, 2002·Respiratory Physiology & Neurobiology·Rute F M Gomes, Jason H T Bates
Oct 23, 2002·Journal of Applied Physiology·Peter D SlyZoltan Hantos
Mar 11, 2003·Journal of Applied Physiology·Jason H T Bates, Charles G Irvin
Jun 5, 2003·Journal of Applied Physiology·Zoltán HantosPeter D Sly
Sep 2, 2003·Journal of Applied Physiology·Gilman Allen, Jason H T Bates
Dec 9, 2003·Journal of Applied Physiology·Scott WagersJason H T Bates
Apr 16, 2005·Journal of Applied Physiology·Gilman B AllenGary F Nieman
Sep 30, 2006·Journal of Applied Physiology·Scott S WagersCharles G Irvin
Dec 2, 2006·Journal of Applied Physiology·Satoru ItoBéla Suki
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Lennart K A LundbladJason H T Bates
Oct 27, 2007·American Journal of Respiratory and Critical Care Medicine·Jason H T BatesCharles G Irvin
Oct 11, 2008·Journal of Applied Physiology·Z HantosB Suki
Jun 30, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason H T BatesCharles G Irvin

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Citations

Mar 3, 2012·Journal of Applied Physiology·Jason H T BatesLennart K A Lundblad
Feb 5, 2011·Journal of Applied Physiology·David W KaczkaZoltán Hantos
Oct 21, 2011·Critical Reviews in Biomedical Engineering·David W Kaczka, Raffaele L Dellacá
Mar 19, 2020·Experimental Biology and Medicine·Renato de L VitorassoHenrique T Moriya

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