PMID: 15374499May 1, 1990Paper

Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial

Archives of Gerontology and Geriatrics
T FülöpI Zs -Nagy

Abstract

A double-blind clinical trial was performed on 50 persons (25 men, 25 women, average age 77 years) suffering from dementias of medium level (DSM III, Category 1, ICD No. 299). All subjects were residents in an old age home. The patients were treated first for 2 weeks by placebo tablets. During this period, body composition parameters were determined and these data served as controls. This was then followed by an 8-week-long treatment with the nootropic drug, centrophenoxine (CPH), 2 g/day distributed in 2x2 tablets of Helfergin(500) (Promonta, Hamburg, F.R.G.), or placebo tablets of identical size. After 8 weeks the laboratory tests were repeated again. The randomization code for verum or placebo treatment was revealed only after completing the trial. Four dropouts occurred during the treatment period. The total body water, extracellular water volume and exchangable Na(+) were determined by means of radioisotope methods. Plasma volume (PV) was measured by indocyanine-green dilution test. Body weights were also recorded. From the above data further parameters could be calculated. Serum lipid data as well as several hormone levels were also checked in the blood samples. The main results were better performance in psychometric tes...Continue Reading

References

Feb 1, 1979·Mechanisms of Ageing and Development·I Zs-Nagy
Nov 21, 1978·Journal of Theoretical Biology·I Zs-Nagy
Jan 1, 1988·Annals of the New York Academy of Sciences·I Zs-NagyI Semsei
May 1, 1982·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·D B Morgan
Sep 1, 1980·Mechanisms of Ageing and Development·I Nagy, K Nagy
Jan 1, 1981·Gerontology·J R Cox, W A Shalaby
Nov 25, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·B J Burke, G E Staddon

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Citations

Mar 1, 1991·Archives of Gerontology and Geriatrics·I Zs -Nagy
Jun 30, 1994·Annals of the New York Academy of Sciences·I Zs-Nagy
Jan 8, 2021·Chemistry & Biodiversity·Karol JędrejkoBożena Muszyńska

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