PMID: 2512238Sep 1, 1989Paper

Effects of cerebral blood flow on hypoxic ventilatory response--a human study by jugular venous blood sampling

[Hokkaido igaku zasshi] The Hokkaido journal of medical science
A Suzuki

Abstract

To assess the effect of cerebral blood flow on hypoxic ventilatory response in humans, internal jugular venous blood and arterial blood gases and ventilation were measured simultaneously and repeatedly in fifteen healthy male volunteers in two settings: 1) progressive and subsequent sustained isocapnic hypoxia (PetO2 = 45 Torr), and 2) stepwise and progressive hypercapnia. Jugular venous-arterial PCO2 difference decreased significantly from 8.7 Torr at control to 7.4 Torr at 1 min, and 6.4 Torr at 5 and 15 min of sustained hypoxia, probably due to the increase in cerebral blood flow. Corrected hypoxic ventilatory response (HVR) (1.27 +/- 0.75 1/min/%), which was calculated with the product of change in jugular venous PCO2 (PjCO2) and the value of hypercapnic ventilatory response on PjCO2 (delta VE/delta PjCO2), was significantly higher than the actually measured HVR (0.52 +/- 0.45 1/min/%). However, the magnitude of this correction did not correlate with the original HVR. Ventilation decreased significantly during sustained hypoxia from 16.5 +/- 5.3 1/min at 1 min to 14.1 +/- 6.9 1/min (p less than 0.05) at 15 min of hypoxia. Such ventilatory depression was remarkable in the low responders, whose HVR were lower than the average...Continue Reading

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