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Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase

Science

Sep 23, 1994

Z S HuangMichael A Moskowitz

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Abstract

The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) ac...read more

Mentioned in this Paper

Mice, Inbred C57BL
Neuroglia
Posterior Choroidal Artery Infarction
Mutant
Arginine hydrochloride
Cerebral Ischemia
Blood Vessel
Amino Acid Oxidoreductases
Metazoa
Metabolic Inhibition
115
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Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase

Science

Sep 23, 1994

Z S HuangMichael A Moskowitz

PMID: 7522345

DOI: 10.1126/science.7522345

Abstract

The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient in neuronal NO synthase (NOS) ac...read more

Mentioned in this Paper

Mice, Inbred C57BL
Neuroglia
Posterior Choroidal Artery Infarction
Mutant
Arginine hydrochloride
115

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  • Citations885
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