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Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease

Acta Neuropathologica

Nov 30, 2006

E RockensteinEliezer Masliah

Abstract

Cerebrolysin (CBL) is a peptide mixture with neurotrophic effects that might reduce the neurodegenerative alterations in Alzheimer's disease (AD). We have previously shown that in the amyloid precursor protein (APP) transgenic (tg) mouse model of AD, CBL improves synaptic plasticity and...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Microtubule-Associated Protein 3
Caspase-3
Neurons
Amyloid Beta Precursor Protein Measurement
Astrocytes
Promoter
Alzheimer's Disease
Cell Proliferation
Genus Hippocampus
Paper Details
References
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  • Citations42
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  • References55
  • Citations42
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Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease

Acta Neuropathologica

Nov 30, 2006

E RockensteinEliezer Masliah

PMID: 17131129

DOI: 10.1007/s00401-006-0166-5

Abstract

Cerebrolysin (CBL) is a peptide mixture with neurotrophic effects that might reduce the neurodegenerative alterations in Alzheimer's disease (AD). We have previously shown that in the amyloid precursor protein (APP) transgenic (tg) mouse model of AD, CBL improves synaptic plasticity and...read more

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Microtubule-Associated Protein 3
Caspase-3
Neurons
Amyloid Beta Precursor Protein Measurement
Astrocytes
Promoter
Alzheimer's Disease
Cell Proliferation
Genus Hippocampus

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The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Astrocytes & Amyloid

The relationship between astrocytes and amyloid has been suggested in some neurological diseases such as Alzheimer’s disease. Neuronal damage stimulates the activation of reactive astrocytes, which may the source of amyloid that forms in Alzheimer’s. Here is the latest research on astrocytes and amyloid.

Related Papers

Paper Details
References
  • References55
  • Citations42
12345...
  • References55
  • Citations42
12345
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