Effects of cerium oxide nanoparticles to fish and mammalian cell lines: An assessment of cytotoxicity and methodology

Toxicology in Vitro : an International Journal Published in Association with BIBRA
P RosenkranzJ M Navas

Abstract

Two cerium oxide nanoparticles (CeO(2) NPs) and one micro-sized CeO(2) particle were thoroughly characterized in their pristine form, in water and in cell culture medium. The particles were tested for cytotoxicity to the H4IIE rat hepatoma cell line or the RTG-2 rainbow trout gonadal cell line by means of four standard cytotoxicity assays. Nominal concentrations were verified by inductively coupled plasma mass spectrometry (ICP-MS) and methods were assessed for their suitability to detect reliably adverse effects due to particle exposure. All three particles showed aggregation in water and media. In the H4IIE cell line, the MTT cytotoxicity test revealed that negative effects could be observed for the CeO(2) NPs after 24h and for all particles after 72h of exposure, making the effects size, concentration and time dependent. No negative effect for the concentrations tested was detected for the remaining three assays and the RTG-2 cell line, making the MTT assay and the H4IIE cell line an appropriate system to assess adverse effects of CeO(2) NPs. A verification of the nominal concentration through ICP-MS revealed that there was a discrepancy between nominal and measured concentration depending on concentration and particle teste...Continue Reading

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Citations

Feb 15, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·G TajuA S Sahul Hameed
Dec 23, 2014·Journal of Agricultural and Food Chemistry·Weilan ZhangXingmao Ma
May 28, 2015·Environmental Science and Pollution Research International·Koigoora SrikanthJanapala Venkateswara Rao
Jul 8, 2015·Chemical Reviews·Hao DongChun-Hua Yan
Dec 2, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Monika KumariParamjit Grover
Oct 4, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Valérie ForestJérémie Pourchez
Feb 11, 2014·International Journal of Toxicology·Monika KumariParamjit Grover
Aug 21, 2013·International Journal of Molecular Sciences·Ivo IavicoliAntonio Bergamaschi
Jul 15, 2020·Materials·Motaharesadat Hosseini, Masoud Mozafari
Aug 16, 2019·Biological Trace Element Research·Afsaneh NematiMohammadreza Gholami
Dec 14, 2018·Frontiers in Endocrinology·Ayushi PriyamShweta Gehlout
Sep 13, 2019·Current Pharmaceutical Design·Jimena CazenaveAndrea Silvana Rossi
Jan 13, 2016·Plant Physiology and Biochemistry : PPB·Weilan ZhangXingmao Ma

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