PMID: 590221Dec 1, 1977

Effects of change in dietary folic acid content on pentylenetetrazol seizure threshold in rat

O R HommesJ C Kok


Pentylenetetrazol (PT) eeg thresholds were measured in rats on a folic acid (FA) deficient diet, normal diet, and a diet supplemented with large amounts of folic acid. The intraperitoneal dose per kilogram body weight of PT is significantly higher in the FA deficient group and significantly lower in the FA supplemented group than in rats on a normal diet. This indicates an effect of FA metabolism on PT epilepsy. The Lactobacillus casei minus Streptococcus faecalis activity of the brain is decreased in the FA deficient and increased in the FA supplemented group. The relation between brain folate metabolism and epilepsy is discussed.


Dec 1, 1975·Journal of the Neurological Sciences·E H ReynoldsI Chanarin
Oct 1, 1973·Journal of the Neurological Sciences·E A Obbens, O R Hommes
Jan 1, 1974·Life Sciences·A J MandellL L Hsu
Jan 1, 1973·Archives of Neurology·D B Smith, L C Racusen
May 1, 1973·Journal of the Neurological Sciences·O R HommesC C Wijffels
Jun 1, 1970·Journal of Virology·L M KozloffS S DeLong
Jan 1, 1970·Neurology·E M AllenD Melamed


Jan 1, 1992·Molecular Neurobiology·S R Snodgrass
Jan 1, 1988·The International Journal of Biochemistry·R E Davis, D J Nicol

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Weber-Fechner Law
Folic Acid, Sodium Salt
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