PMID: 6104411Apr 1, 1980Paper

Effects of changes in acid-base balance on neuromuscular blockade produced by ORG-NC 45

Acta Anaesthesiologica Scandinavica
D I FunkF M Pol

Abstract

The effects of acute acid-base changes on the neuromuscular blocking action of ORG NC 45 (a monoquaternary homologue of pancuronium) were measured in 10 cats, utilizing a constant infusion technique. Partial NC 45 blockade was antagonized slightly in the tibialis, soleus, and diaphragm during respiratory alkalosis (pH 7.53; PaCO2 1.9 kPa), whereas metabolic alkalosis (pH 7.64; Paco2 3.5 kPa) produced significant antagonism of NC 45 block in those muscles. Respiratory acidosis (pH 6.98; Paco2 10.3 kPa) and metabolic acidosis (p H 7.13; PaCO2 4.9 kPa) significantly potentiated partial NC 45 blocks in the tibialis, soleus, and diaphragm (except in the diaphragm during metabolic acidosis). Cumulative dose responses studied in six cats showed that the NC 45 dosage required to produce 85--95% tibialis block was slightly greater than controls during respiratory and metabolic alkalosis. Conversely, significantly less NC 45 was needed to produce the same degree of block during respiratory and metabolic acidosis. In vitro studies in rat hemidiaphragms likewise showed minimal NC 45 block antagonism when pH was raised to 7.68, and significant potentiation under acidotic conditions (pH 7.05). These actions are attributed in part to an incre...Continue Reading

References

Apr 1, 1978·British Journal of Anaesthesia·R D Miller, L L Roderick
Jan 1, 1974·Acta Anaesthesiologica Scandinavica·E J Crul-Sluijter, J F Crul
Aug 1, 1970·British Journal of Anaesthesia·R Hughes
Feb 1, 1960·The Journal of Physiology·A J BULLERR M ECCLES
Jan 1, 1962·Acta Pharmacologica Et Toxicologica·S H JOHANSEN, P F OSGOOD
Mar 1, 1946·British Journal of Pharmacology and Chemotherapy·E BULBRING

❮ Previous
Next ❯

Citations

Jan 1, 1991·Diagnostic Cytopathology·R K Gupta, C Dowle
Feb 19, 1982·Pharmaceutisch Weekblad. Scientific Edition·L H BooijJ E Crul
Apr 12, 2002·Journal of Clinical Anesthesia·Masanori YamauchiAkiyoshi Namiki
Aug 20, 1992·The New England Journal of Medicine·V SegredoR D Miller
Jan 1, 1989·International Journal of Aging & Human Development·J M DaleyJ Jorquez
Mar 8, 2003·European Journal of Anaesthesiology·O A P SantanenM P J Paloheimo
Nov 3, 2005·Tropical Medicine & International Health : TM & IH·Meghna R DesaiFeiko O Ter Kuile
Jan 11, 2008·American Journal of Physiology. Renal Physiology·Ira KurtzMinhtri K Nguyen
Jan 19, 1984·The New England Journal of Medicine·R T JohnsonA Vaisberg
Jun 22, 1989·The New England Journal of Medicine·D E GriffinA Vaisberg
Mar 8, 2003·European Journal of Anaesthesiology·T BouillonA Hoeft
Mar 8, 2003·European Journal of Anaesthesiology·C D HanningE K Perry
Mar 8, 2003·European Journal of Anaesthesiology·R BogdanskiE Kochs
Mar 8, 2003·European Journal of Anaesthesiology·J J LehotO Bastien
Mar 8, 2003·European Journal of Anaesthesiology·B HeindlB F Becker
Mar 8, 2003·European Journal of Anaesthesiology·D HarmonD Lowe
Mar 8, 2003·European Journal of Anaesthesiology·M WestphalG Brodner
Mar 8, 2003·European Journal of Anaesthesiology·K MikawaY Niwa
Mar 8, 2003·European Journal of Anaesthesiology·G KierzekJ L Pourriat
Mar 8, 2003·European Journal of Anaesthesiology·N AnzawaA Matsuki
Mar 8, 2003·European Journal of Anaesthesiology·R TytherG Shorten
Mar 8, 2003·European Journal of Anaesthesiology·H Erolçay, L Yüceyar
Jun 16, 2011·Journal of the American Animal Hospital Association·Manuel Martin-FloresRobin D Gleed
Jan 1, 1983·Annales Françaises D'anesthèsie Et De Rèanimation·J Kienlen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.