PMID: 3890724Apr 1, 1985

Effects of changes in pH, medium, and inoculum size on the in vitro activity of amifloxacin against urinary isolates of Staphylococcus saprophyticus and Escherichia coli

Antimicrobial Agents and Chemotherapy
A IravaniG A Richard

Abstract

The in vitro activity of amifloxacin (WIN 49375), a new fluoroquinolone, was compared with the activities of antimicrobial agents that are commonly used for the treatment of urinary tract infection (cinoxacin, cephalexin, gentamicin, amoxicillin, trimethoprim, and trimethoprim-sulfamethoxazole) against 25 strains of Staphylococcus saprophyticus and 28 strains of Escherichia coli. Bacterial strains were isolated from urine specimens of college women with acute urinary tract infections. Bacterial isolates were more susceptible to trimethoprim-sulfamethoxazole, trimethoprim, and amifloxacin than to the other drugs tested. The in vitro activity of amifloxacin against S. saprophyticus had an inverse relation to increases in the pH of the test medium. Changes in the type of culture medium had no effect on the in vitro activity of amifloxacin. There was a direct relationship between increases in inoculum size and the MICs of amifloxacin.

References

Apr 1, 1978·Journal of Clinical Pathology·W A GillespieA L Hilton
Oct 1, 1980·The Journal of Infectious Diseases·P A JordanH Baer
Jul 1, 1981·Antimicrobial Agents and Chemotherapy·P R Murray, J H Jorgensen

Citations

Jan 1, 1987·Antimicrobial Agents and Chemotherapy·D J PohlodM M Somerville
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·C PelletierP Bourlioux
Feb 4, 2011·Research in Microbiology·Zeynep Erdogan-YildirimMarkus Zeitlinger
Feb 1, 1988·Journal of Clinical Pharmacology·P B Fernandes
Feb 1, 1988·Journal of Clinical Pharmacology·H C Neu
Dec 2, 2016·BMC Complementary and Alternative Medicine·Jing-Jing GuoChao-Dong Qian

Related Concepts

Win 49375
Microbicides
Antibiotics
Bacteriuria
Ciprinol
Alkalescens-Dispar Group
Hydrogen-Ion Concentration
Fungus Drug Sensitivity Tests
Quinolines
Genus staphylococcus

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