Effects of Charged Particles on Human Tumor Cells

Frontiers in Oncology
Kathryn D HeldAkihisa Takahashi

Abstract

The use of charged particle therapy in cancer treatment is growing rapidly, in large part because the exquisite dose localization of charged particles allows for higher radiation doses to be given to tumor tissue while normal tissues are exposed to lower doses and decreased volumes of normal tissues are irradiated. In addition, charged particles heavier than protons have substantial potential clinical advantages because of their additional biological effects, including greater cell killing effectiveness, decreased radiation resistance of hypoxic cells in tumors, and reduced cell cycle dependence of radiation response. These biological advantages depend on many factors, such as endpoint, cell or tissue type, dose, dose rate or fractionation, charged particle type and energy, and oxygen concentration. This review summarizes the unique biological advantages of charged particle therapy and highlights recent research and areas of particular research needs, such as quantification of relative biological effectiveness (RBE) for various tumor types and radiation qualities, role of genetic background of tumor cells in determining response to charged particles, sensitivity of cancer stem-like cells to charged particles, role of charged pa...Continue Reading

References

Jan 1, 1992·Radiation and Environmental Biophysics·G KraftM Scholz
Nov 1, 1989·International Journal of Radiation Biology·G G SteelJ H Peacock
Nov 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S M BentzenJ Meder
May 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G G Steel, J H Peacock
Jan 1, 1985·International Journal of Radiation Oncology, Biology, Physics·M V WilliamsJ F Fowler
May 1, 1971·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S B Field, S Hornsey
Aug 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B StenerlöwJ Carlsson
Jan 1, 1994·International Journal of Radiation Biology·D T Goodhead
Nov 1, 1994·International Journal of Radiation Biology·J F Ward
Jun 1, 1997·International Journal of Radiation Biology·J DenekampJ F Fowler
Feb 7, 2001·International Journal of Radiation Biology·K AndoM Urano
Apr 11, 2000·International Journal of Radiation Biology·A TakahashiT Ohnishi
May 11, 2000·Journal of Radiation Research·D T Goodhead
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·M SuzukiK Ando
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·H MatsuzakiK Isono
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·Y IwadateH Tsujii
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·M SuzukiK Ando
Oct 30, 2001·International Journal of Radiation Biology·A TakahashiT Ohnishi
May 15, 2002·Radiation Research·Betsy M SutherlandJacques Laval
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Harald PaganettiHerman D Suit
Aug 27, 2002·International Journal of Radiation Biology·L M PerssonA Brahme
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Friedo Zölzer, Christian Streffer
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Kazufumi KagawaTatsuaki Kanai
May 17, 2003·Science·Monica Garcia-BarrosRichard Kolesnick
Jan 1, 1997·Apoptosis : an International Journal on Programmed Cell Death·K D Held
Jan 23, 2004·Nature Reviews. Cancer·Ricardo PardalSean J Morrison
Feb 6, 2004·American Journal of Clinical Oncology·Yoshifumi MatsuiTakenori Ochiai
Apr 1, 2004·British Journal of Cancer·H WillersS N Powell
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Akihisa TakahashiTakeo Ohnishi
Dec 14, 2004·The Oncologist·Peter Vaupel, Louis Harrison
Mar 2, 2005·Nature Reviews. Cancer·J Martin Brown, Laura D Attardi
Jul 2, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Søren M Bentzen, Mark A Ritter
Aug 16, 2005·Cancer Cell·Zvi Fuks, Richard Kolesnick
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Patrick A KupelianArul Mahadevan
Oct 8, 2005·Journal of Radiation Research·Ryoichi HirayamaKoichi Ando
Nov 22, 2005·International Journal of Radiation Biology·A TakahashiT Ohnishi
Jan 18, 2006·International Journal of Radiation Oncology, Biology, Physics·Tatsuaki KanaiHirohiko Tsujii

❮ Previous
Next ❯

Citations

Mar 26, 2016·Frontiers in Oncology·Anne-Sophie WoznyClaire Rodriguez-Lafrasse
Apr 14, 2017·Physics in Medicine and Biology·T TessonnierK Parodi
Oct 5, 2017·Physics in Medicine and Biology·Christian P Karger, Peter Peschke
Oct 21, 2018·Journal of Cancer Research and Clinical Oncology·Mahdi AbbasianDavid A Lightfoot
Jan 10, 2019·Journal of Radiation Research·Ming Tsuey ChewAndrew Nisbet
Dec 12, 2018·Radiation Research·Narongchai AutsavaprompornTeruaki Konishic
Aug 23, 2019·The British Journal of Radiology·Valentina DiniMaria Antonella Tabocchini
Jul 19, 2017·Cancers·Ifigeneia V MavraganiAlexandros G Georgakilas
Sep 10, 2019·Technology in Cancer Research & Treatment·Francois ChevalierYannick Saintigny
Jul 1, 2018·International Journal of Particle Therapy·Simon Deycmar, Martin Pruschy
Jul 1, 2018·International Journal of Particle Therapy·Shayoni RaySylvain V Costes
Jul 1, 2018·International Journal of Particle Therapy·Christine E HellwegChrista Baumstark-Khan
Jul 9, 2020·International Journal of Molecular Sciences·Camille HuartAnne-Catherine Wéra
Oct 25, 2020·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·N ChegeniM Hassanvand
Dec 5, 2020·International Journal of Particle Therapy·Michelle E HowardChris J Beltran
Feb 28, 2018·International Journal of Radiation Oncology, Biology, Physics·Radhe MohanJacek Capala
May 25, 2021·Frontiers in Oncology·Wanrong LuoNing-Ang Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
X-ray
xenografts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.