Abstract
The mechanism by which an endocardial-epicardial activation rate gradient develops after 1 or 2 min of sustained ventricular fibrillation is unknown. We recorded from electrodes on the epicardium and from hook electrodes in the endocardium in three open-chest control dogs during prolonged ventricular fibrillation. The same recordings were also made in seven dogs after right ventricular subendocardial ablation with Lugol solution and in three dogs after substitution of air for the cavitary blood. The effects of these interventions, i.e., Lugol ablation (n = 2) and the exposure to air (n = 2), on the subendocardial Purkinje fiber transmembrane action potential properties were also evaluated in vitro using microelectrode recording techniques. The in vivo studies showed a significant endocardial-epicardial rate gradient in the control dogs and in dogs that had air substituted for the cavitary blood. In comparison, in dogs that underwent chemical subendocardial ablation, the activation cycle lengths for the endocardium and epicardium were not significantly different. The in vitro studies showed that subendocardial Purkinje fiber action potentials could still be recorded for up to 10 min of exposure to air. In comparison, in the tiss...Continue Reading
Citations
Feb 7, 2004·Circulation Research·Jonathan C NewtonRaymond E Ideker
Sep 18, 2007·Circulation Research·Marina CerroneJosé Jalife
Oct 13, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Stéphane MasséKumaraswamy Nanthakumar
Nov 12, 2003·Circulation·Peng-Sheng ChenJames N Weiss
Aug 19, 2007·Circulation·Paul B TabereauxRaymond E Ideker
Apr 3, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Tyson G TaylorAlexey V Zaitsev
Jun 11, 1998·Circulation Research·O Berenfeld, J Jalife
Dec 10, 2003·Circulation·Dietmar BänschKarl-Heinz Kuck
Oct 6, 2007·Journal of Cardiovascular Electrophysiology·J Scott AllisonRaymond E Ideker
Aug 5, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Tsu-Juey WuChih-Tai Ting
Aug 31, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Paul W VenableAlexey V Zaitsev
Apr 13, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Li LiRaymond E Ideker
Apr 15, 2011·Journal of Cardiovascular Electrophysiology·Tsu-Juey WuChih-Tai Ting
Jul 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Derek J DosdallRaymond E Ideker