Effects of chemoreflexes on hyperthermic hyperventilation and cerebral blood velocity in resting heated humans

Experimental Physiology
Naoto FujiiTakeshi Nishiyasu

Abstract

We tested the hypothesis that hyperthermic hyperventilation in part reflects enhanced chemoreceptor ventilatory O(2) drive, and that the resultant hypocapnia attenuates ventilatory responses and/or middle cerebral artery mean blood velocity (MCAV(mean)) in resting humans. Eleven healthy subjects were passively heated for 50-80 min, causing oesophageal temperature (T(oes)) to increase by 1.6 degrees C. During heating, minute ventilation increased (P < 0.05), while end-tidal CO(2) pressure (P(ET,CO(2))) and MCAV(mean) declined. A hyperoxia test in which three breaths of hyperoxic air were inspired was performed once before heating and three times during the heating. When we observed hypocapnia (P(ET,CO(2)) below 40 mmHg), P(ET,CO(2)) was restored to the eucapnic level by adding 100% CO(2) to the inspired air immediately before the last two tests. Minute ventilation was significantly reduced by hyperoxia, and that reduction gradually increased with increasing T(oes). However, the percentage decrease in from the normoxic level was small (20-29%) and unchanged during heating. When P(ET,CO(2)) was restored to eucapnic levels, was unchanged, but MCAV(mean) was partly restored to the level seen prior to heating (28.1% restoration at T(...Continue Reading

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Citations

May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Bun TsujiTakeshi Nishiyasu
Jan 3, 2016·Autonomic Neuroscience : Basic & Clinical·Zachary J SchladerCraig G Crandall
Jul 16, 2013·Experimental Physiology·Zachary J SchladerCraig G Crandall
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Jun 24, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bun TsujiTakeshi Nishiyasu
Jan 30, 2018·The Journal of Physiology·Michael J JoynerBlair D Johnson
Dec 6, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Craig G CrandallBlair D Johnson
Sep 14, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naoto FujiiTakeshi Nishiyasu
Jul 19, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rebekah A I LucasCraig G Crandall
Jan 30, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bun TsujiTakeshi Nishiyasu
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Sep 13, 2008·Journal of Applied Physiology·Naoto FujiiTakeshi Nishiyasu
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May 6, 2020·The Journal of Physiological Sciences : JPS·Manabu ShibasakiShigehiko Ogoh
Mar 12, 2011·Journal of Applied Physiology·Keiji HayashiTakeshi Nishiyasu
May 3, 2014·Journal of Applied Physiology·Shigehiko OgohManabu Shibasaki
Aug 19, 2017·Journal of Applied Physiology·James T DavisAndrew T Lovering
Oct 13, 2020·Medicine and Science in Sports and Exercise·Naoto FujiiTakeshi Nishiyasu
Nov 25, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Phillip J WallaceStephen S Cheung

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