Effects of Chemotherapy and Radiotherapy on Spermatogenesis: The Role of Testicular Immunology

International Journal of Molecular Sciences
Ning QuKou Sakabe

Abstract

Substantial improvements in cancer treatment have resulted in longer survival and increased quality of life in cancer survivors with minimized long-term toxicity. However, infertility and gonadal dysfunction continue to be recognized as adverse effects of anticancer therapy. In particular, alkylating agents and irradiation induce testicular damage that results in prolonged azoospermia. Although damage to and recovery of spermatogenesis after cancer treatment have been extensively studied, there is little information regarding the role of differences in testicular immunology in cancer treatment-induced male infertility. In this review, we briefly summarize available rodent and human data on immunological differences in chemotherapy or radiotherapy.

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Citations

Sep 29, 2019·Andrology·A Gauthier-FisherC L Librach
Oct 5, 2019·Andrologia·Sanaz ZiaeipourMohammad-Amin Abdollahifar
Jul 15, 2020·Andrologia·Marlon Martinez, Ahmad Majzoub
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Aug 25, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Jan-Bernd StukenborgOlle Söder

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Methods Mentioned

BETA
biopsy

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