DOI: 10.1101/461087Nov 5, 2018Paper

Effects of childhood maltreatment on social cognition and brain functional connectivity in borderline personality disorder patients

BioRxiv : the Preprint Server for Biology
X. DuqueF. Pellicer


Borderline personality disorder (BPD) is a chronic condition characterized by high levels of impulsivity, affective instability, and difficulty to establish and manage interpersonal relationships. This paper assessed differences in performance on social cognitive paradigms (MASC, RMTE) and how it related to child abuse. Specifically, it evaluated the relationship between performance on cognitive paradigms and baseline brain connectivity in patients with BPD, compared to healthy controls.\n\nBPD patients had higher levels of childhood maltreatment, increased impulsivity and aggression, and more dissociative symptoms than control subjects. For the sexual abuse subdimension, there were no differences between the BPD and the control groups, but there was a negative correlation between MASC scores and total childhood maltreatment levels, as well as between physical abuse, physical negligence, and MASC. Both groups showed that the higher the level of childhood maltreatment, the lower the performance on the MASC social cognitive test. Further, in the BPD group, there was hypoconnectivity between the structures responsible for emotion regulation and social cognitive responses that have been described as part of the frontolimbic circuit...Continue Reading

Software Mentioned

Movie for the Assessment of Social Cognition ( MASC )
ART Artifact Detection Tools
- X
fMRI Functional Connectivity toolbox

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