Effects of Chinese Dietary Pattern of Fat Content, n-6/n-3 Polyunsaturated Fatty Acid Ratio, and Cholesterol Content on Lipid Profile in Rats

BioMed Research International
Xian-Guo ZouZe-Yuan Deng

Abstract

This study aims to investigate the effect of Chinese diet pattern of fat content (30% or 36.06%), n-6/n-3 polyunsaturated fatty acid (PUFA) ratio (5 : 1 or 9 : 1), and cholesterol content (0.04 or 0.057 g/kg total diet) on lipid profile using a rat model. Results showed that rats' body weights (BWs) were controlled by the simultaneous intakes of cholesterol level of 0.04 g/kg total diet and n-6/n-3 ratio of 5 : 1. In addition, under high-fat diet, increased cholesterol feeding led to increased total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels and decreased triacylglycerols (TG) in rats' plasma. However, high density lipoprotein cholesterol (HDL-C) level and the ratios of HDL-C/LDL-C and HDL-C/TC in rats' plasma increased in response to simultaneous intakes of low n-6/n-3 ratio (5 : 1) and cholesterol (0.04 g/kg total diet) even under high-fat diet. Moreover, as the n-6/n-3 PUFA ratio in the diet decreased, the proportion of n-3 PUFAs increased in plasma, liver, and muscle and resulted in the decrease of n-6/n-3 PUFA ratio.

References

Aug 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R P Mensink, M B Katan
Mar 1, 1990·Metabolism: Clinical and Experimental·C C ParrishA Angel
May 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M Klagsbrun, E R Edelman
Oct 1, 1985·Metabolism: Clinical and Experimental·S WongP Nestel
Apr 1, 1994·Journal of Nutritional Science and Vitaminology·Y F Lu, H L Wu
Jan 3, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·U N Das
Jul 26, 2003·QJM : Monthly Journal of the Association of Physicians·K W Lee, G Y H Lip
Aug 18, 2004·Journal of the American College of Nutrition·Paola BenattiMenotti Calvani
Oct 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Simopoulos
Mar 10, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Thomas BrennaUNKNOWN International Society for the Study of Fatty Acids and Lipids, ISSFAL
May 23, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J D Buckley, P R C Howe
Jan 17, 2012·Journal of Agricultural and Food Chemistry·Lin LeiZe-Yuan Deng
Apr 27, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S Eilat-AdarB V Howard
Aug 31, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N GuelzimD Hermier

❮ Previous
Next ❯

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.