Effects of Chinese herbal medicine on modulating the course of puberty development in children with precocious puberty

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
De-pei CaiPin Li

Abstract

To explore the therapeutic effects of Ziyin Xiehuo Recipe (ZYXHR) for nourishing yin and lowering fire and Yishen Tianjing Recipe (YSTJR) for nourishing kidney and replenishing essence on regulating the gonadotrophic and somatotrophic functions of hypothalamic-pituitary axis, and to reveal the mechanisms of ZYXHR and YSTJR in modulating the course of pubertal development of children with precocious puberty. The pubertal rats were fed with ZYXHR or YSTJR for 30 days, and the parameters of rats were monitored as the followings: The content of gonadotropin-releasing hormone (GnRH), the frequency and amplitude of GnRH impulse releasing, the releasing amounts of aminoacid neurotransmitters, and neuropeptide Y (NPY) and beta-endorphin (beta-END) in the gonadotrophic area of the hypothalamus were detected with neurobiological methods (push-pull perfusion, homogenate, incubation of brain slices, and immunohistochemical staining). The levels of gene and protein expressions of GnRH, growth hormone releasing hormone (GHRH) and somatostatin (SS) in hypothalamus, and follicular stimulating hormone (FSH), luteinizing hormone (LH) and growth hormone (GH) in adenohypophysis as well as insulin-like growth factor I (IGF-I) in metaphysis were det...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·W C WetselA Negro-Vilar
May 1, 1984·Endocrinology·J P Bourguignon, P Franchimont
Sep 2, 2004·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Hao ShenBo-Ying Chen

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Citations

Mar 1, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Sun Haeng LeeGyu Tae Chang
Jul 1, 2008·Social Work in Health Care·Kai-fong ChanKa-ying Ng

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