PMID: 8597879Nov 1, 1995Paper

Effects of chlomipramine and fluoxetine on subcutaneous carrageenin-induced inflammation in the rat

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
M BianchiF Berti

Abstract

We have previously shown that, after acute administration, antidepressant drugs exert anti-inflammatory actions in rats. In this study we evaluated the effects of 3 different doses of chlomipramine (10, 20, and 40 mg/kg i.p), and fluoxetine (5.0, 10, and 20 mg/kg i.p.) on subcutaneous carrageenin-induced inflammation. Both drugs dose-dependently reduced the inflammatory exudate, as well as the PGE2-like bio- and immunoactivity in the exudate. Chlomipramine dose-dependently reduced substance P concentrations in the exudate, whereas fluoxetine was effective only at the highest dose. Our results confirm that antidepressant drugs are able to reduce the development of inflammation in the rat and suggest that the inhibition of substance P production might play a role in mediating the anti-inflammatory effects of chlomipramine.

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Mar 15, 1975·Experientia·P Krupp, M Wesp
Apr 1, 1987·British Medical Bulletin·J C Foreman
Nov 1, 1989·Annals of the Rheumatic Diseases·F Y Lam, W R Ferrell
Dec 1, 1967·European Journal of Pharmacology·E A MartelliN Corsico
Sep 22, 1994·European Journal of Pharmacology·M BianchiA E Panerai
Aug 1, 1994·Agents and Actions·D MichelsonE M Sternberg
Nov 1, 1994·General Pharmacology·D T ScottW R Ferrell
Aug 1, 1994·Pharmacology, Biochemistry, and Behavior·M BianchiA E Panerai

❮ Previous
Next ❯

Citations

Jun 25, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·V HajhashemiA Talebi
Dec 4, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omar M E Abdel-SalamMahmoud S Arbid
Dec 2, 2000·European Journal of Pharmacology·L BardinA Eschalier
Jan 29, 1997·European Journal of Pharmacology·P SacerdoteA E Panerai
Oct 18, 2000·Journal of Psychosomatic Research·R Maunder
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·T C Pellegrino, B M Bayer
Jun 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omar M E Abdel-SalamSiham M El-Shenawy
May 5, 1999·Fundamental & Clinical Pharmacology·M BianchiA E Panerai
Oct 5, 2011·Journal of Periodontology·Luciana S Branco-de-AlmeidaPedro L Rosalen
Sep 29, 2011·Cell Biochemistry and Function·Stefani VirchevaMargarita Kirkova
Aug 31, 2010·Cell Biochemistry and Function·Margarita KirkovaMarta Kubera
Jan 3, 2012·Immunopharmacology and Immunotoxicology·Luciana VismariJoão Palermo-Neto
Jul 4, 2012·International Immunopharmacology·Hui-Chen SuChiung-Wen Tsao
Jun 10, 2006·Trends in Pharmacological Sciences·Juan A MicóAlain Eschalier
Jan 10, 2014·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·José Alves GurgelRonaldo Albuquerque Ribeiro
May 12, 2006·International Clinical Psychopharmacology·Nicoletta BrunelloJulien Mendlewicz
Jan 16, 2008·CNS Drugs·Gary McCleane
Oct 21, 2004·The Journal of Pharmacology and Experimental Therapeutics·Carrie K JonesHarlan E Shannon
Aug 9, 2017·Canadian Journal of Physiology and Pharmacology·Behnam GhorbanzadehSoheila Alboghobeish
Apr 3, 2018·European Journal of Pharmacology·Ahmed BarakatMohamed M Elbadr
Apr 7, 2019·Biochimie·Thomas DhenainTereza Coman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here