PMID: 6148394Aug 1, 1984Paper

Effects of chlorbutol on 45Ca movements and contractile responses of rat aorta and its relevance to the actions of Syntocinon

The Journal of Pharmacy and Pharmacology
S BarrigónJ Tamargo

Abstract

The effects of chlorbutol (0.7, 1.4 and 2.8 mM) on the contractile responses induced by KCl and noradrenaline (NA) and on 45Ca movements have been studied on rat isolated thoracic aorta. Chlorbutol decreased, in a dose-dependent manner, contractions induced by KCl and NA and this effect was observed whether it was added before or after the induced contractions. Preincubation with chlorbutol inhibited the contractile responses elicited by addition of Ca (1-5 mM) to Ca-free high-potassium solution. It also inhibited in a dose-dependent manner the 45Ca influx but increased 45Ca efflux in rat aortic strips. These results suggest that chlorbutol decreases peripheral resistance by reducing the availability of intracellular Ca to the contractile machinery in vascular smooth muscle cells. The effects of synthetic oxytocin (Syntocinon) at concentrations containing the same chlorbutol concentration were quantitatively similar from those produced by chlorbutol alone. Therefore, the inhibitory cardiovascular effects ascribed previously to synthetic oxytocin may be attributed to its preservative, chlorbutol, and not to oxytocin itself.

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Citations

May 8, 1985·European Journal of Pharmacology·S BarrigónM T Tejerina
Mar 29, 1988·European Journal of Pharmacology·T TejerinaJ Tamargo
Aug 3, 1993·European Journal of Pharmacology·T TejerinaP Gonzalez
Nov 3, 1995·Journal of Chromatography. B, Biomedical Applications·T J Amiss, I W Smoak
Feb 17, 2000·European Journal of Pharmacology·E RuizT Tejerina
Sep 1, 1997·General Pharmacology·K YamanagaY Kagitani
Jun 1, 1991·British Journal of Pharmacology·R CarrónJ Tamargo
Aug 1, 1996·British Journal of Pharmacology·M Del RioT Tejerina
Jan 1, 1991·The Journal of Pharmacy and Pharmacology·A UbedaA Villar
Dec 14, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·N VimalaS Kumar
Jan 15, 2002·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A U LokugamageC H Rodeck
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·M NishikawaN Nakamura
Jan 9, 2004·British Medical Bulletin·Hazem El-Refaey, Charles Rodeck
Jan 30, 2009·American Journal of Physiology. Cell Physiology·Hidetada MatsuokaMasumi Inoue
Apr 1, 1986·British Journal of Pharmacology·S Barrigón, J Tamargo
Jun 1, 1989·British Journal of Pharmacology·J Tamargo, T Tejerina

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