PMID: 3006110Jan 1, 1986

Effects of chlordiazepoxide training dose on the mixed agonist-antagonist properties of benzodiazepine receptor antagonist Ro 15-1788, in a drug discrimination procedure

Psychopharmacology
J De Vry, J L Slangen

Abstract

In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro 15-1788 plus 20 mg/kg CDP. Ro 15-1788 (0.63-40 mg/kg) dose-dependently antagonized CDP, and induced predominantly saline appropriate responding when administered alone. Thereafter, the same rats were retrained by progressively decreasing the training dose, to discriminate 2.5 mg/kg CDP from saline, and were tested again with the same compounds. Ro 15-1788 (0.16-40 mg/kg) now failed to antagonize CDP (2.5 mg/kg) and increased the percentage of drug-appropriate responding in a dose-related manner when administered alone. In experiment 2, separate groups of rats (n = 10) were similarly trained to discriminate either 15 or 3 mg/kg CDP from saline. Tests with CDP, Ro 15-1788 and Ro 15-1788 plus CDP (either 15 or 3 mg/kg) yielded similar results to experiment 1, suggesting that the training dose effects on generalization and antagonism of Ro 15-1788 were not affected by the manner in which the lower CDP dose acquired dru...Continue Reading

References

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Citations

Jan 1, 1986·Psychopharmacology·Ian P StolermanI C Rose
Jan 1, 1989·Psychopharmacology·F Woudenberg, J L Slangen
Oct 1, 1994·Psychopharmacology·T R Levesque, K W Locke
Jan 1, 1996·Psychopharmacology·J A White, Ian P Stolerman
Mar 13, 1990·European Journal of Pharmacology·F Woudenberg, J L Slangen
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·C R Gardner
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·M G CordaW Fratta
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F Woudenberg, T H Hijzen
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A Van HestB Olivier
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·C R GardnerF L Parker
Jan 1, 1990·Pharmacology & Therapeutics·J S Andrews, D N Stephens
Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·J M WitkinJ E Barrett
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·M D Schechter
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·N A Ator
Aug 3, 2011·Behavioural Pharmacology·Ian P StolermanKathleen A Grant

Related Concepts

Metazoa
Benzodiazepinones
Brain
Librium
Cues
Discrimination Learning
Drug Interactions
Romazicon
Generalization, Stimulus
August Rats

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