Effects of chlorine dioxide on thyroid function in the African green monkey and the rat

Journal of Toxicology and Environmental Health
R M HarringtonJ P Bercz

Abstract

In a previous study from this laboratory, chlorine dioxide (ClO2) treated drinking water depressed thyroxine (T4) levels in the African green monkey. The present study again demonstrated a decrease in T4 levels in the same species after 4 wk of oral exposure. However, after 8 wk of treatment T4 levels rebounded to above pretreatment levels, coinciding with an increase in thyroid radioiodide uptake. This T4 rebound phenomenon and increased iodide uptake may be due to a compensatory endocrinological mechanism. In rats, T4 levels dropped during the 8-wk ClO2 treatment period in a dose-dependent manner, and no rebound effect was observed. Iodide uptake values in the rat were not affected. It appears that ClO2 may have an effect on thyroid function in both species.

References

Mar 1, 1978·Metabolism: Clinical and Experimental·R C SawhneyG K Rastogi
Jan 1, 1985·Journal of Toxicology and Environmental Health·J OrmeR J Bull
Aug 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R M HarringtonJ P Bercz

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Citations

Apr 8, 2006·Archives of Environmental Health·Najwa OuhoummaneSuzanne Gingras
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·F Brucker-Davis
Feb 1, 1990·Regulatory Toxicology and Pharmacology : RTP·R P Smith, C C Willhite
Apr 3, 1999·Toxicology and Industrial Health·P Short, T Colborn
Jan 1, 1988·Journal of Toxicology and Environmental Health·G D Fisher, W W Kilgore
May 31, 2012·Journal of Clinical Immunology·Maria Angela Zaccarelli-Marino
Mar 1, 1991·Journal of Toxicology and Environmental Health·J E SimmonsE Berman

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