PMID: 8950222Oct 21, 1996Paper

Effects of chloroquine in hematoporphyrin-treated animals

Chemico-biological Interactions
N G EggerK E Anderson

Abstract

Porphyrins and related compounds are useful in photodynamic therapy but can cause cutaneous photosensitivity. We determined whether chloroquine, which is effective in treating porphyria cutanea tarda, would mobilize an administered porphyrin from tissues and enhance its excretion. Hematoporphyrin with and without chloroquine was administered to chick embryos, mice, and rats. Tissue and plasma porphyrin levels were markedly increased after hematoporphyrin dosing. Porphyrin concentrations in liver, spleen, and kidney were not significantly affected by chloroquine. Total urinary and fecal porphyrin excretion in rats treated with hematoporphyrin (50 mg/kg, i.p.) was not influenced by chloroquine treatment (100 mg/kg, s.c.). Excretion of heptacarboxylporphyrin, normally a minor fraction of urinary porphyrins, was significantly increased in chloroquine-treated rats. These results suggest that chloroquine is unlikely to be useful after photodynamic therapy for mobilizing exogenous porphyrins from tissues such as liver, spleen, and kidney. Increased urinary excretion of heptacarboxylporphyrin may contribute to the beneficial effect of chloroquine in porphyria cutanea tarda.

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T J Dougherty, S L Marcus
Mar 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D E Goeger, K E Anderson
Jan 1, 1985·Archives of Dermatological Research·G GoerzH Merk
Oct 1, 1973·The Journal of Investigative Dermatology·P L ScholnickH S Marver
Sep 1, 1972·The British Journal of Dermatology·J J TaljaardS M Joubert
Nov 1, 1984·The British Journal of Dermatology·R E AshtonI A Magnus
May 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·C K Lim, T J Peters
Mar 17, 1993·Journal of the National Cancer Institute·H I Pass

❮ Previous
Next ❯

Citations

Oct 19, 2013·International Journal of Dermatology·Suzanne TintleDawn Marie R Davis
Feb 19, 2019·International Journal of Dermatology·Julia Elisa Cabezas ArteagaVitor Manoel Silva Dos Reis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.