Effects of chlorpheniramine, pyrilamine and astemizole on intracranial self-stimulation in rats

European Journal of Pharmacology
A Wauquier, C J Niemegeers

Abstract

Rats implanted in the lateral hypothalamus were used to assess lever pressing for brain stimulation. Lever pressing was increased dose-dependently by chlorpheniramine and decreased dose-dependently by pyrilamine. Astemizole, a new orally long-acting antihistamine did not affect self-stimulation. Evidence from pharmacological tests based on altered neurotransmitter functions suggests that the central anticholinergic activity of chlorpheniramine is probably responsible for the increased response rate, whereas the central dopamine receptor blocking activity of pyrilamine may be responsible for the decreased response rate. Astemizole is a specific antihistamine devoid of any central activity.

References

Nov 1, 1976·European Journal of Pharmacology·A Wauquier, C J Niemegeers

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Citations

Jan 6, 1987·European Journal of Pharmacology·C R CalcuttI R Smith
Oct 25, 2003·European Journal of Pharmacology·Maryam EidiLeili Sepehrara
Oct 2, 2002·European Journal of Pharmacology·Mohammad-Reza ZarrindastShahrbano Oryan
Dec 9, 2003·Behavioural Brain Research·F R FaganelloR Mattioli
May 9, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·C C MedalhaR Mattioli
Aug 14, 2008·Pharmacology, Biochemistry, and Behavior·J A Rojas-ZamoranoJ Velazquez Moctezuma
Mar 1, 2006·Biomedical Chromatography : BMC·Elzbieta Brzezińska, Grazyna Kośka
Feb 11, 2000·Japanese Journal of Pharmacology·T SuzukiK Onodera
Apr 20, 2012·Acta Biologica Hungarica·L Lénárd, Z Karádi

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