PMID: 8443566Jan 1, 1993Paper

Effects of chlorpromazine on phosphatidylserine biosynthesis in rat pup brain exposed to ethanol in utero

Neurochemistry International
P G RhodesG Y Sun

Abstract

Phosphatidylserine biosynthesis in rat pup brain was examined by assaying the serine base-exchange enzyme activity in the microsomal and plasma membrane fractions, and by measuring the incorporation of [3H]serine into phosphatidylserine in brain slices and in the intact brain. Chlorpromazine, either added in vitro into the incubation system or administered to animals via i.p. injection or feeding a liquid diet, gave rise to an increase in the phosphatidylserine biosynthesis activity. Ethanol administered in the form of a liquid diet to pregnant rats (day 11 birth) resulted in a decrease in phosphatidylserine biosynthesis in the newborn and developing brain. The ethanol-induced decrease in phosphatidylserine biosynthetic activity could be reversed by adding chlorpromazine to the ethanol diet. Results demonstrate that phosphatidylserine biosynthesis in the neonatal brain is affected in opposite directions by chlorpromazine and ethanol. This poses the possibility that chlorpromazine administration may be effective in alleviating the deleterious effects caused by the decreased phosphatidylserine biosynthesis in brain due to in utero ethanol exposure.

References

Mar 30, 1978·Biochimica Et Biophysica Acta·T Taki, J N Kanfer
Jun 1, 1992·Alcoholism, Clinical and Experimental Research·Z Y HuP G Rhodes
Dec 1, 1989·Journal of Neurochemistry·U LeliG Hauser
Jan 1, 1985·The International Journal of Biochemistry·S Tsakiris, G Deliconstantinos
Jun 24, 1982·Brain Research·A C FosterC W Cotman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here