Effects of cholecystokinin (CCK)-JMV-180 on the CCK receptors of rabbit pancreatic acini and gallbladder smooth muscle

Japanese Journal of Pharmacology
H TaniguchiH Tamaki

Abstract

Effects of cholecystokinin (CCK)-JMV-180, a CCK analog, on the CCK receptor functions of isolated rabbit pancreatic acini and gallbladder smooth muscle were studied. When the pancreatic acini were incubated with increasing concentrations of CCK-8, stimulation of amylase release reached a maximum at 3 nM and then declined with the increasing concentration of CCK-8. CCK-JMV-180 also caused a dose-dependent amylase release stimulation, which plateaued and remained unchanged above 300 nM at about 50% of the maximal stimulation by CCK-8. CCK-JMV-180 above 100 nM caused a rightward shift of the downstroke of the dose-response curve for CCK-8 (pA2 = 7.5). In the gallbladder smooth muscle, CCK-8 caused a dose-dependent contraction, but CCK-JMV-180 totally lacked this property. Instead, CCK-JMV-180 caused a rightward shift of the dose-response curve for CCK-8 (pA2 = 7.9). These results suggest that CCK-JMV-180 distinguishes between the CCKA receptors associated with pancreatic exocrine secretion in the acini and those involved in contraction of the isolated gallbladder smooth muscle in rabbits.

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J HughesG N Woodruff
Oct 1, 1987·Biochimica Et Biophysica Acta·M YounesJ D Gardner
Nov 1, 1988·International Journal of Peptide and Protein Research·P FulcrandJ Martinez
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Dec 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·M CeskaB Brown
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R T JensenJ D Gardner

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Citations

Aug 5, 1999·British Journal of Pharmacology·L RomanelliP Valeri
Apr 22, 2004·British Journal of Pharmacology·Gábor VargaMassimo D'Amato
May 23, 1996·European Journal of Pharmacology·H TaniguchiM Nagasaki

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