PMID: 8971925Jan 1, 1996Paper

Effects of cholecystokinin octapeptide (CCK-8) on food intake in adult and aged rats under different feeding conditions

Peptides
J P VoigtH Fink

Abstract

The effects of CCK on food intake were investigated under fixed feeding conditions in comparison to a test meal taken after 16 h of food deprivation. The experiments were performed on young adult rats (8 weeks old) as well on aged rats (23 months old). Intraperitoneal CCK-8 (8 and 40 micrograms/kg) significantly reduced the size of a test meal following 16-h food deprivation. This effect was independent of the age of the rats. However, under fixed feeding conditions neither of the doses used in this study reduced food intake in the young adult rats, whereas the highest dose of 40 micrograms/kg did so in the aged rats. These results suggest that the hypophagic effect of exogenous CCK-8 depends on experimental conditions, food intake being reduced after a period of food deprivation but not under a fixed feeding regimen in adult animals. Furthermore, the data suggest that age is a factor contributing to the complex behavioral actions of CCK, because only old animals were more susceptible to an anorectic action of CCK under the fixed feeding schedule. An explanation may lie in an interaction of other known behavioral effects of CCK (e.g., anxiogenic, mnemonic action) with its effects under the different feeding schedules.

References

Sep 15, 1977·Life Sciences·F L Greenway, G A Bray
Jun 24, 1976·Nature·R A Sturdevant, H Goetz
May 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Harro, L Oreland
Jan 1, 1991·Progress in Neurobiology·A J Silver, J E Morley
Jan 1, 1994·Peptides·J N Crawley, R L Corwin
Aug 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·M VoitsH Fink
Sep 1, 1995·Archives of Gerontology and Geriatrics·K MiyasakaA Funakoshi

❮ Previous
Next ❯

Citations

Jan 11, 2000·Behavioural Brain Research·A T KonkleC Bielajew
Oct 31, 2000·Nutrition·C MacIntoshI M Chapman
Jun 11, 2002·Annual Review of Nutrition·Barbara A HorwitzRoger B McDonald
Jan 12, 2016·Animals : an Open Access Journal From MDPI·Silke DietzeJörg-Peter Voigt
Sep 3, 2011·Journal of Neurochemistry·Christian P MüllerMaria A De Souza Silva
Dec 29, 2004·Physiology & Behavior·Patrick Tso, Min Liu
Jul 21, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Ian McPhee Chapman
May 26, 2004·Physiology & Behavior·Patrick Tso, Min Liu
Nov 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter KobeltHubert Mönnikes
Mar 28, 2017·Reviews in the Neurosciences·Santiago Ballaz
Aug 12, 1999·Zeitschrift für Gerontologie und Geriatrie·D Baez-Franceschi, J E Morley
Aug 10, 2002·Annals of Surgery·Tilman T ZittelEkkehard C Jehle
Nov 12, 2003·Experimental Biology and Medicine·Min LiuPatrick Tso
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M LiuP Tso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.