PMID: 1064048May 1, 1976

Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops

Proceedings of the National Academy of Sciences of the United States of America
A M Feldman, S W Brusilow

Abstract

To evaluate a possible role for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] and adenosine 3':5'-cyclic monophosphate in the secretion of endolymph, we studied the effect of an intra-scala media injection of purified cholera toxin (an adenylate cyclase stimulant) on cochlear endolymph volume, endolymphatic potential, and endolymphatic Na and K concentrations.

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Related Concepts

Central Nervous System Stimulant [EPC]
Central Nervous System Stimulants
Adenosine
Endolymph
Potassium
Process of Secretion
Anasarca
Sodium
Adenylyl Cyclase 9
Stimulant

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