PMID: 1064048May 1, 1976

Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops

Proceedings of the National Academy of Sciences of the United States of America
A M Feldman, S W Brusilow


To evaluate a possible role for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC] and adenosine 3':5'-cyclic monophosphate in the secretion of endolymph, we studied the effect of an intra-scala media injection of purified cholera toxin (an adenylate cyclase stimulant) on cochlear endolymph volume, endolymphatic potential, and endolymphatic Na and K concentrations.


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