PMID: 8600975Mar 15, 1996Paper

Effects of cholesterol on the lamellar and the inverted hexagonal phases of dielaidoylphosphatidylethanolamine

Biochimica Et Biophysica Acta
H TakahashiI Hatta

Abstract

Effects of cholesterol on the lamellar and the inverted hexagonal (HII ) phases of dielaidoylphosphatidylethanolamine (DEPE) were studied by means of not only differential scanning calorimetry (DSC) but also simultaneous X-ray diffraction and DSC (XDDSC). XDDSC shows that structural changes are related to thermotropic events of the mixtures. Addition of cholesterol to DEPE induces to broaden the transition from the lamellar gel (L beta) to lamellar liquid-crystalline (L alpha) phase. In fact, in the broad transition region, a coexistence of two lamellar X-ray diffraction peaks of the L beta and L alpha phases take place. In samples containing above 30 mol% cholesterol, no peak at the L beta-L alpha phase transition was observed in the DSC thermogram. On the other hand, cholesterol causes biphasic effects on the L alpha-HII phase transition: At low cholesterol concentrations below 20 mol%, the incorporation of cholesterol reduces the transition temperature and at high cholesterol concentrations about 30 mol%, the transition temperature increases by addition of cholesterol. Based upon the results of X-ray diffraction, the thermal expansion coefficients of lattice spacings, i.e., the temperature dependence of lattice spacings, wer...Continue Reading

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Citations

Jan 25, 2008·European Biophysics Journal : EBJ·Doreen KessnerReinhard H H Neubert
Feb 27, 2003·Biochemical and Biophysical Research Communications·Ryouta Maeba, Nobuo Ueta
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