PMID: 3762310Oct 13, 1986Paper

Effects of choline augmentation on acetylcholine synthesis and release in rat atrial minces

Life Sciences
E M Meyer, S P Baker

Abstract

The uptake and acetylation of [3H]-choline, as well as the calcium-dependent release of a newly synthesized [3H]-ACh, was studied in a new rat atrial mince preparation. The hemicholinium-3-sensitive uptake and acetylation of [3H]-choline increased as [3H]-choline concentrations were elevated to 100 microM in atrial minces. In contrast, hemicholinium-3-sensitive [3H]-choline uptake was saturated with 15 microM [3H]-choline in brain synaptosomes. The increased atrial [3H]-ACh synthesized in the presence of [3H]-choline augmentation was releasable by 50 mM K+-depolarization in a 1 mM cobalt-sensitive manner. These results suggest that atrial parasympathetic activity may be more sensitive to circulating choline concentrations than brain cholinergic neurons are.

References

Mar 12, 1976·Science·R L Schuyler
Jul 21, 1978·Science·R E Sievers, J E Sadlowski

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Citations

Dec 4, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Yesim Ozarda IlcolIsmail H Ulus
Feb 5, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ke WuEdwin M Meyer
Sep 22, 2007·European Journal of Pharmacology·Mehmet CansevIsmail Hakki Ulus
Apr 23, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zeki YilmazIsmail H Ulus
Aug 1, 1987·Neurochemical Research·D F Bottiglieri, E M Meyer
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T KawadaK Sunagawa

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