Effects of cholinergic drugs on ureteral function in anesthetized dogs

The Journal of Urology
Yoshitaka TomiyamaNobuo Shibata

Abstract

We evaluated the effects of the nonselective muscarinic receptor agonist carbachol (CCh) and its antagonist atropine on ureteral function in anesthetized dogs. Drug effects were evaluated on elevated pressure in a completely obstructed ureter and peristalsis in its partially obstructed fellow ureters as well as on intravesical isovolumetric pressure. CCh (0.1 to 1.0 microg/kg intravenously) dose dependently decreased elevated pressure and peristalsis in completely and partially obstructed ureters, respectively, and increased intravesical isovolumetric pressure. On the other hand, atropine (0.1 to 1.0 mg/kg intravenously) had no significant effects on these 3 variables. Prior administration of atropine (1.0 mg/kg intravenously) completely inhibited the described CCh induced effects. Our results demonstrate that in anesthetized dogs cholinergic receptor stimulation has a suppressive effect on ureteral pressure and peristalsis in obstructed ureters, in contrast to its activation of bladder smooth muscle.

References

Jun 1, 1992·Journal of Autonomic Pharmacology·L RiveraA García-Sacristán
Jan 1, 1989·Developmental Pharmacology and Therapeutics·J LatifpourR M Weiss
Jun 1, 1986·The Journal of Urology·T MoritaR M Weiss
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Apr 12, 2003·Naunyn-Schmiedeberg's Archives of Pharmacology·Yoshitaka TomiyamaNobuo Shibata

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Citations

May 13, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·G RaynalJ Petit
Aug 19, 2015·Autonomic Neuroscience : Basic & Clinical·M J NguyenR J Lang
Nov 28, 2009·Acta Physiologica Hungarica·F OsmanGy L Nádasy
May 15, 2007·Urologia Internationalis·A Erdem CandaOktay Nazli
May 2, 2009·Drugs·Vassilios TzortzisJean J M C H de la Rosette

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