PMID: 1583028Apr 1, 1992Paper

Effects of chronic administration of atenolol on the in situ perfused mesentery of normotensive and hypertensive rats

Journal of Autonomic Pharmacology
A J DraperM H Todd

Abstract

1. Atenolol 50 mg kg-1 was administered daily for 7 to 21 days to male normotensive Wistar rats and to Okamoto spontaneously hypertensive rats. Blood pressure and heart rate were monitored daily. 2. Following atenolol treatment the response to exogenous noradrenaline and to periarterial nerve stimulation was measured in the in situ blood perfused mesentery. 3. In normotensive animals, treatment with atenolol for 7 days had little effect on the responses of the mesenteric vasculature to either exogenous noradrenaline or to periarterial nerve stimulation. After 21 days, the response to noradrenaline was little changed, but there was a statistically significant decrease in the response to periarterial nerve stimulation at the higher stimulation frequencies (16 and 35 Hz). 4. In spontaneously hypertensive animals, treatment with atenolol for 7 days did not significantly affect the response of the mesenteric vasculature to either noradrenaline or periarterial nerve stimulation; however, after treatment for 21 days, responses to exogenous noradrenaline were reduced, while responses to periarterial nerve stimulation were even more markedly reduced, particularly at the lower stimulus frequencies. 5. The time course of the observed effe...Continue Reading

References

Oct 1, 1977·Physiological Reviews·T C Westfall
May 17, 1975·British Medical Journal·L HanssonA Westerlund
Dec 1, 1988·Hypertension·R J GryglewskiJ R Vane
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·T C Westfall, M J Meldrum
Aug 29, 1980·European Journal of Pharmacology·E K Jackson, W B Campbell
Jan 1, 1984·British Journal of Clinical Pharmacology·A SalvettiB Abdel-Haq

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