Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

Behavioural Brain Research
N RuedaC Martínez-Cué

Abstract

The Ts65Dn mouse is the most commonly used model of Down syndrome. This mouse shows many phenotypic characteristics present in people with Down syndrome, including behavioral and cognitive deficits. SGS-111 is a novel analogue of the nootropic piracetam, which prevents oxidative damage and apoptosis in both normal and Down syndrome human cortical neurons. In this work we tested the ability of chronic administration of SGS-111 to adult Ts65Dn mice to reverse the cognitive deficit found in these mice. Moreover, since oxidative stress has been reported as early as the fetal stage, SGS-111 was also administered to pregnant Ts65Dn females from the day of conception throughout the pregnancy and to Ts65Dn pups during their entire life (5 months), from birth to the end of the behavioral testing period. A characterization of the effects of SGS-111 treatment on Ts65Dn and control mice sensorimotor abilities, motor coordination, spontaneous activity, activity in the open field, exploration, anxiety and spatial and non-spatial short- and long-term learning and memory was performed. The behavioral characterization showed that chronic administration of the antioxidant SGS-111 reduced the hyperactivity shown by Ts65Dn mice in their home cage,...Continue Reading

References

Jan 13, 1978·Brain Research·D S OltonF H Gage
Jan 1, 1987·Cytogenetics and Cell Genetics·M T Davisson, E C Akeson
Oct 1, 1995·Nature Genetics·R H ReevesM T Davisson
Oct 20, 1995·Neuroscience Letters·R M EscorihuelaJ Flórez
Aug 20, 1996·Brain Research. Developmental Brain Research·M DierssenJ Flórez
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M HoltzmanW C Mobley
Jul 1, 1997·European Journal of Drug Metabolism and Pharmacokinetics·T A GudashevaS B Seredenin
Apr 1, 1998·Behavioural Brain Research·G E DemasP J Yarowsky
Jul 9, 1998·Neuroscience Letters·R M EscorihuelaA Fernández-Teruel
Oct 29, 1998·Neuroscience Letters·A M InsaustiT F Vallina
Jan 16, 1999·Neurobiology of Learning and Memory·C G Ambrogi LorenziniG Tassoni
Jan 8, 2000·Physiology & Behavior·A C CostaM T Davisson
May 5, 2001·Brain Research. Brain Research Reviews·Z GaldzickiS I Rapoport
Aug 21, 2002·Stress : the International Journal on the Biology of Stress·C BaamondeM Dierssen
Sep 25, 2002·Life Sciences·George CaponeMichael Trush
Nov 7, 2002·Physiology & Behavior·Timothy H MoranJohn D Gearhart
Mar 11, 2003·Child Development·Bruce F PenningtonLynn Nadel
Mar 19, 2003·Behavioural Brain Research·Heather A Bimonte-NelsonAnn-Charlotte E Granholm
Apr 25, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alejandra PelsmanJorge Busciglio
May 7, 2003·Neuroscience and Biobehavioral Reviews·Christopher R Pryce, Joram Feldon
Sep 30, 2003·The American Journal of Psychiatry·Stefan J TeipelHarald Hampel
Aug 11, 2004·Behavioural Brain Research·Melissa R Stasko, Alberto C S Costa
Oct 30, 2004·The Journal of Comparative Neurology·Pavel V BelichenkoWilliam C Mobley
Jun 1, 2005·Neuroscience Letters·Alberto C S Costa, Michael J Grybko
May 30, 2006·Nature Neuroscience·James B AimoneFred H Gage
Jun 27, 2006·Comptes rendus biologies·Philippe Taupin

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Citations

Sep 4, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Daniel Z Wetmore, Craig C Garner
Jun 12, 2012·Neural Plasticity·Noemí RuedaCarmen Martínez-Cué
May 16, 2009·Expert Opinion on Therapeutic Patents·Philippe Taupin
Mar 19, 2011·Brain Research Bulletin·Vasily VorobyovFrank Sengpiel
Jan 26, 2010·Progress in Neurobiology·Andrea ContestabileLaura Gasparini
Oct 27, 2015·Frontiers in Behavioral Neuroscience·Fiorenza StagniRenata Bartesaghi
Dec 31, 2011·Biochimica Et Biophysica Acta·Ira T Lott
Aug 9, 2011·Reviews in the Neurosciences·Renata BartesaghiElisabetta Ciani
Oct 11, 2017·Disease Models & Mechanisms·Yann HeraultVeronique Brault
Nov 21, 2012·Nature Reviews. Neuroscience·Mara Dierssen
Jul 9, 2009·Physiological Reviews·Mara DierssenXavier Estivill
Feb 28, 2014·Current Opinion in Obstetrics & Gynecology·Fayçal GuedjJean-Maurice Delabar
Aug 7, 2020·Antioxidants·Noemí Rueda Revilla, Carmen Martínez-Cué

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