Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys

Psychopharmacology
Nicole H Mutschler, J Bergman

Abstract

Dopamine D1 receptor partial agonists have been proposed as candidate medications for the treatment of cocaine dependence. However, there currently is scant information regarding how chronic exposure to D1 agonists may modify behavioral effects of cocaine and, especially, whether tolerance develops to their effects on cocaine self-administration. The present studies were conducted to evaluate the effects of chronic treatment with the D1 receptor partial agonist SKF 77434 on IV cocaine self-administration in rhesus monkeys. A protocol was developed to rapidly evaluate the effects of chronic drug exposure on extinction behavior, threshold dose of self-administered cocaine, and the dose-effect function for cocaine self-administration behavior. Monkeys performed in daily sessions of IV cocaine self-administration under a fixed-ratio schedule of reinforcement and food presentation under either a fixed-ratio or fixed-interval schedule of reinforcement. When both types of performance were stable, chronic exposure to SKF 77434 followed with month-long regimens of IV treatment with each of two or three dosages. The effects of SKF 77434 were dose-related. Exposure to 1.0 mg/kg per day of SKF 77434 yielded a moderate and persistent rightw...Continue Reading

Citations

Jan 30, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diana MartinezMarc Laruelle
Sep 5, 2002·Nature Reviews. Drug Discovery·Mary Jeanne KreekEduardo Butelman
Nov 9, 2007·Behavioural Pharmacology·Rajeev I DesaiCarol A Paronis
Jul 6, 2004·Drugs·David A GorelickZheng-Xiong Xi
Mar 6, 2012·Neuroscience Letters·Pamela SabioniJosé C F Galduróz
Apr 9, 2009·Pharmacology, Biochemistry, and Behavior·Su-xia LiLin Lu
Sep 4, 2004·Addictive Behaviors·John GrabowskiS Stevens Negus
Jun 30, 2006·Biological Psychiatry·Matthew W FeltensteinRonald E See
Sep 11, 2007·Biochemical Pharmacology·Leonard L Howell, Heather L Kimmel
Jul 18, 2021·The Journal of Pharmacology and Experimental Therapeutics·Paul W Czoty, Michael A Nader

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