Effects of chronic alcohol consumption and withdrawal on the response of the male and female hypothalamic-pituitary-adrenal axis to acute immune stress

Brain Research
Susana M Silva, M Dulce Madeira

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in the response to stress, and its activity is sexually dimorphic and modulated by sex steroids. Recent work indicates that HPA axis functioning is disturbed by chronic alcohol consumption and subsequent withdrawal in rats of both sexes, but particularly in females. To examine the influence of sex steroid hormones in HPA axis response to acute stress after ingestion of a 20% ethanol solution over 6months and subsequent withdrawal (2months), intact males, and estradiol- and oil-injected ovariectomized females received a single intraperitoneal injection of lipopolysaccharide (LPS). Six hours after LPS administration, corticosterone concentrations were increased in all male groups; however, in ethanol-treated rats they remained below those of control and withdrawn rats. mRNA levels of corticotrophin-releasing hormone (CRH) increased, and were identical in all groups after LPS stimulation, whereas those of vasopressin, although increased, remained below control levels. LPS stimulation elevated corticosterone concentrations in all oil-injected female groups, but did not alter those of estradiol-injected females. In oil- and estradiol-injected ethanol-treated females,...Continue Reading

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Citations

Apr 6, 2013·Pflügers Archiv : European journal of physiology·Lynda Sharrett-FieldMark A Prendergast
Jan 17, 2016·Pharmacological Reviews·Jill B Becker, George F Koob
Jan 2, 2016·Pharmacological Reviews·Styliani GoulopoulouR Clinton Webb
Jun 17, 2014·Alcoholism, Clinical and Experimental Research·Pablo N SurkinJavier Fernández-Solari
Jun 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adam D CollierDavid J Echevarria
Oct 8, 2019·Alcoholism, Clinical and Experimental Research·Manuel Sanchez-AlavezBruno Conti
Dec 17, 2019·Alcoholism, Clinical and Experimental Research·Jung S Kim, Rémi Martin-Fardon
Apr 3, 2020·Phytotherapy Research : PTR·Laura MicheliStefano Pallanti
Apr 25, 2020·Brain Research·Sierra SimpsonOlivier George

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