Effects of chronic and acute training on glucocorticoid receptors concentrations in rats

Life Sciences
Chen PeijieXu Renbao

Abstract

The effects of chronic endurance training and acute exercise on glucocorticoid receptors were investigated in rats. For chronic endurance training, rats were exposed to progressive running training on a motor-driven treadmill for 3, 5 and 7 weeks, twice a day and 6 days a week. The samples were taken, 34-36 hours after the last exercise bout. Some of the 7-week training rats were killed by decapitation 7 days following the last exercise bout. The glucocorticoid receptors in hepatic cytosol in 5-week and 7-week rats decreased as compared to the sedentary control. There was no significant difference between the glucocorticoid receptors in hepatic cytosol in some of the 7-week rats those who had stopped training for 7 days and those in the controls. The chronic endurance training did not lead to change of the apparent dissociation constant (Kd). The changes of glucocorticoid receptors after acute exercise have also been investigated and it showed profound decreases of glucocorticoid receptors in renal and myocardial cytosol in low intensity (swimming without an extra weight for 60 minutes) and high intensity (swimming with a weight equal to 6% of body mass for 60 minutes) training groups. The decreases in glucocorticoid receptors ...Continue Reading

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Citations

Feb 4, 2010·European Journal of Pharmacology·Ivana ElakovićGordana Matić
Jan 6, 2015·Stress : the International Journal on the Biology of Stress·Matias M PulopulosAlicia Salvador
Feb 2, 2011·Brain Research·Ivana ElakovićGordana Matić
Nov 5, 2014·European Journal of Applied Physiology·Roy J Shephard, Nathan Johnson
Aug 12, 2016·Journal of Physical Therapy Science·Ana Claudia PetriniAdriana Pertille
Sep 30, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C C F NascimentoA C Mattiello-Sverzut
Jun 23, 2010·Journal of Muscle Research and Cell Motility·Antonios MatsakasKetan Patel
Sep 24, 2005·The European Journal of Neuroscience·Gerlinde A MetzLori K Smith

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