PMID: 8958581Dec 3, 1996Paper

Effects of chronic central administration of losartan on the cardiovascular and hormonal responses to hemorrhage in conscious rats

Regulatory Peptides
E K YangH J Kim

Abstract

Our objective was to assess the effects of chronic central angiotensin II (Ang II) blockade on the basal regulation of blood pressure, heart rate (HR), arginine vasopressin (AVP), renin, epinephrine (EPI), norepinephrine (NE) and on cardiovascular and hormonal responses to hemorrhage in conscious rats. Losartan (4 micrograms/h), or artificial cerebrospinal fluid (aCSF), was chronically infused into a lateral ventricle by using an osmotic minipump for 6 days at a rate of 1 microliter/h. Compared with aCSF controls, chronic losartan treatment significantly decreased the basal level of blood pressure (from 117 +/- 2.3 to 106 +/- 2.2 mmHg, P < 0.01) and increased the HR (from 357 +/- 3.7 to 410 +/- 6.6 beats/min, P < 0.01). Plasma renin concentration increased 3-fold (from 6.1 +/- 0.6 to 19.2 +/- 1.6 ng.ml(-1).h(-1), P < 0.01). Basal levels of AVP, EPI and NE were not different between two groups. Blood pressure immediately after hemorrhage and its compensatory recovery following hemorrhage was not different in both groups. Immediately after hemorrhage, however, in the losartan-treated rats, the HR was distinctly lower than that of aCSF controls, even at 10 min after hemorrhage. Hemorrhage produced a significant increase in the pla...Continue Reading

References

Sep 1, 1992·Trends in Pharmacological Sciences·U M SteckelingsT Unger
Jun 1, 1992·Hypertension·M J DePasqualeM L Mangiapane
Jan 1, 1987·Annual Review of Physiology·M I Phillips

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Citations

Dec 15, 2010·Clinical and Experimental Pharmacology & Physiology·Dmitry N Mayorov
Apr 28, 2004·Autonomic Neuroscience : Basic & Clinical·J R Potas, R A L Dampney
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M MorrisT M Coffman
Nov 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mostafa A El-HaddadMichael G Ross
Nov 24, 2019·European Journal of Pharmacology·Maycon I O MilanezRuy R Campos

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