Abstract
Our objective was to assess the effects of chronic central angiotensin II (Ang II) blockade on the basal regulation of blood pressure, heart rate (HR), arginine vasopressin (AVP), renin, epinephrine (EPI), norepinephrine (NE) and on cardiovascular and hormonal responses to hemorrhage in conscious rats. Losartan (4 micrograms/h), or artificial cerebrospinal fluid (aCSF), was chronically infused into a lateral ventricle by using an osmotic minipump for 6 days at a rate of 1 microliter/h. Compared with aCSF controls, chronic losartan treatment significantly decreased the basal level of blood pressure (from 117 +/- 2.3 to 106 +/- 2.2 mmHg, P < 0.01) and increased the HR (from 357 +/- 3.7 to 410 +/- 6.6 beats/min, P < 0.01). Plasma renin concentration increased 3-fold (from 6.1 +/- 0.6 to 19.2 +/- 1.6 ng.ml(-1).h(-1), P < 0.01). Basal levels of AVP, EPI and NE were not different between two groups. Blood pressure immediately after hemorrhage and its compensatory recovery following hemorrhage was not different in both groups. Immediately after hemorrhage, however, in the losartan-treated rats, the HR was distinctly lower than that of aCSF controls, even at 10 min after hemorrhage. Hemorrhage produced a significant increase in the pla...Continue Reading
References
Sep 1, 1977·Life Sciences·J D Peuler, G A Johnson
Jul 1, 1977·Neuropharmacology·W E HoffmanJ F Weet
Jun 1, 1992·Journal of Cardiovascular Pharmacology·T KimuraS Satoh
Jul 24, 1992·Brain Research·D C HogartyM I Phillips
Sep 1, 1992·Trends in Pharmacological Sciences·U M SteckelingsT Unger
Jun 1, 1992·Hypertension·M J DePasqualeM L Mangiapane
Apr 1, 1991·Journal of Hypertension·K H BerecekM H Thorstad
May 1, 1991·Hypertension·F M BumpusP B Timmermans
Mar 26, 1991·Regulatory Peptides·B P RoweR C Speth
Feb 10, 1986·Life Sciences·V A CameronW A Sadler
Feb 8, 1986·British Medical Journal·K Sander-JensenT W Schwartz
Jan 1, 1987·Annual Review of Physiology·M I Phillips
Sep 1, 1973·Acta Physiologica Scandinavica·T Sjöstrand
Nov 1, 1970·Acta Physiologica Scandinavica·B Oberg, S White
Mar 21, 1983·Life Sciences·T BaumE J Sybertz
Sep 1, 1983·Hypertension·T OkunoS Oparil
Nov 1, 1980·Endocrinology·W McDonaldB Moffitt
Mar 1, 1995·Hypertension·D WielboM I Phillips
Dec 10, 1993·Regulatory Peptides·R GyurkoM I Phillips
Citations
Jul 4, 1998·Regulatory Peptides·C H GelbandM K Raizada
Apr 29, 1998·Regulatory Peptides·C H GelbandM K Raizada
Mar 8, 2000·Brain Research Bulletin·A IsraelC I Gutierez
Dec 15, 2010·Clinical and Experimental Pharmacology & Physiology·Dmitry N Mayorov
Sep 8, 2005·Brain Research Bulletin·Yukihiko HagiwaraTakao Kubo
Aug 28, 2013·Physiology & Behavior·Iracema Gomes AraujoAndre Souza Mecawi
Apr 28, 2004·Autonomic Neuroscience : Basic & Clinical·J R Potas, R A L Dampney
Apr 16, 2010·Physiological Reviews·Hayo CastropCharlotte Wagner
Dec 20, 2007·Journal of Hypertension·Akis A AmfilochiadisJohn S Floras
Aug 31, 1999·Journal of Hypertension·D X LimaR A Santos
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M MorrisT M Coffman
Nov 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mostafa A El-HaddadMichael G Ross
Nov 24, 2019·European Journal of Pharmacology·Maycon I O MilanezRuy R Campos