PMID: 15374370Sep 1, 1992Paper

Effects of chronic codergocrine mesylate administration on the brain somatostatinergic system in aged rats

Archives of Gerontology and Geriatrics
K TanakaA Mori

Abstract

Codergocrine mesylate (dihydroergotoxine; DHET), which is an ergot derivative, has been reported to counteract some age-induced impairments in brain function, but the mechanism of these effects is not known. We examined the effect of chronic DHET administration on the somatostatinergic system in the brains of aged rats. Intraperitoneal injections of DHET (1 mg/kg per day) or of vehicle were given to aged rats for 14 days, and resulted in a significant increase in somatostatin (SOM) receptor binding in all six brain regions examined except the hindbrain. DHET had no effect on SOM receptor binding in the brains of young-adult rats. However, the SOM concentration in aged rats was nearly identical to that in young-adult rats and the SOM concentration in different brain areas did not change after chronic administration of DHET. Thus, the present results suggest that chronic administration of DHET can ameliorate at least one of the age-induced impairments of brain somatostatinergic function.

References

Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·C BourasJ Constantinidis
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·J SirviöP J Riekkinen
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C B Srikant, Y C Patel
Nov 14, 1983·Brain Research·J EpelbaumY Agid
Apr 10, 1980·Nature·T HökfeltM Schultzberg

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