Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model

Neuroscience
J MikaB Przewlocka

Abstract

Neuropathic pain is a severe clinical problem, often appearing as a co-symptom of many diseases or manifesting as a result of damage to the nervous system. Many drugs and agents are currently used for the treatment of neuropathic pain, such as tricyclic antidepressants (TCAs). The aims of this paper were to test the effects of two classic TCAs, doxepin and amitriptyline, in naïve animals and in a model of neuropathic pain and to determine the role of cytokine activation in the effects of these drugs. All experiments were carried out with Albino-Swiss mice using behavioral tests (von Frey test and the cold plate test) and biochemical analyses (qRT-PCR and Western blot). In the mice subjected to chronic constriction injury (CCI), doxepin and amitriptyline attenuated the symptoms of neuropathic pain and diminished the CCI-induced increase in the levels of spinal interleukin (IL)-6 and -1β mRNA, but not the protein levels of these cytokines, measured on day 12. Unexpectedly, chronic administration of doxepin or amitriptyline for 12 days produced allodynia and hyperalgesia in naïve mice. The treatment with these drugs did not influence the spinal levels of IL-1β and IL-6 mRNA, however, the protein levels of these pronociceptive fact...Continue Reading

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Citations

Oct 27, 2016·Neuroscience·Mélanie KremerMichel Barrot
Oct 26, 2016·Journal of Photochemistry and Photobiology. B, Biology·Ana Laura Martins de AndradeNivaldo Antônio Parizotto
Mar 12, 2017·Lasers in Medical Science·Ana Laura Martins de AndradeNivaldo Antonio Parizotto
Aug 6, 2020·Anesthesiology and Pain Medicine·Young-Chang AraiTakahiro Ushida
Feb 7, 2020·Neurotoxicity Research·Agnieszka Wawrzczak-BargiełaRyszard Przewłocki
May 22, 2020·Neuroscience and Biobehavioral Reviews·Lidia BravoEsther Berrocoso
Oct 3, 2020·Best Practice & Research. Clinical Anaesthesiology·Ivan UritsOmar Viswanath

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