Effects of chronic electrical stimulation on paralyzed expiratory muscles.

Journal of Applied Physiology
Anthony F DiMarco, Krzysztof E Kowalski

Abstract

Following spinal cord injury, the expiratory muscles develop significant disuse atrophy characterized by reductions in their weight, fiber cross-sectional area, and force-generating capacity. We determined the extent to which these physiological alterations can be prevented with electrical stimulation. Because a critical function of the expiratory muscles is cough generation, an important goal was the maintenance of maximal force production. In a cat model of spinal cord injury, short periods of high-frequency lower thoracic electrical spinal cord stimulation (SCS) at the T(10) level (50 Hz, 15 min, twice/day, 5 days/wk) were initiated 2 wk following spinalization and continued for a 6-mo period. Airway pressure (P)-generating capacity was determined by SCS. Five acute, spinalized animals served as controls. Compared with controls, initial P fell from 43.9 +/- 1.0 to 41.8 +/- 0.7 cmH(2)O (not significant) in the chronic animals. There were small reductions in the weight of the external oblique, internal oblique, transverses abdominis, internal intercostal, and rectus abdominis muscles (not significant for each). There were no significant changes in the population of fast muscle fibers. Because prior studies (Kowalski KE, Romani...Continue Reading

Associated Clinical Trials

Jun 29, 2005·Anthony F. DimarcoAnthony F. Dimarco
Aug 8, 2012·Anthony F. Dimarco

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Citations

Sep 2, 2010·Fiziologiia cheloveka·V A Safonov, N N Tarasova
Jan 2, 2010·Experimental Neurology·Stephanie C JeffersonDena R Howland
Feb 15, 2019·Journal of Applied Physiology·Krzysztof E KowalskiAnthony F DiMarco
Sep 15, 2012·The Tohoku Journal of Experimental Medicine·Misa MiuraMasahiro Kohzuki
Apr 13, 2017·Frontiers in Human Neuroscience·Jan T HachmannIgor A Lavrov

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