PMID: 104868Dec 1, 1978

Effects of chronic epileptic foci on control of pyramidal tract neurons in monkeys

A R Wyler, K J Burchiel


Five Macaca mulatta monkeys were operantly conditioned to control the firing patterns of single precentral pyramidal tract neurons. The accuracy with which the monkeys could control normal PTNs from within the focus was significantly poorer than PTNs from contralateral, homotopic cortex. In comparison to nonepileptic monkeys, there was no significant difference in the accuracy with which PTNs from cortex contralateral to interictal foci were controlled. By contrast, comparison of the time necessary to gain accurate control over individual PTNs from contralateral cortex showed the epileptic monkeys to be significantly encumbered when compared to nonepileptic monkeys. These data suggest that interictal foci produce "noise" in remote regions of brain that are involved in an operant task requiring a high degree of discrimination.


Mar 1, 1978·Brain : a Journal of Neurology·A K Coughlan, E K Warrington
Jan 1, 1971·Brain : a Journal of Neurology·E A Karol, D N Pandya
May 1, 1967·Electroencephalography and Clinical Neurophysiology·J S Lockard, R I Barensten
Sep 1, 1973·Experimental Neurology·A R WylerA A Ward
Feb 1, 1967·Archives of Neurology·D A Prince, B J Wilder


Sep 1, 1980·European Journal of Pediatrics·D Dralle, R H Bödeker
May 18, 1981·Brain Research·A R Wyler, K J Burchiel
Mar 1, 1979·Journal of the Neurological Sciences·R HeipertzK H Karstens
Jan 1, 1985·Journal of the Neurological Sciences·I BengaG Benga
Jul 1, 1980·Neuropharmacology·T E AlbertsonL G Stark
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·R ChaistitwanichD V Sisson
Jan 1, 1990·Brain Research. Brain Research Reviews·J W McDonald, M V Johnston
Feb 5, 1990·Neuroscience Letters·J W McDonaldM V Johnston

Related Concepts

Insula of Reil
Operant Conditioning
Hemispheric Specialization
Macaca mulatta
Corticobulbar Tracts
Non-epileptic Convulsion

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