PMID: 9144646Jan 1, 1997Paper

Effects of chronic ethanol treatment and ethanol withdrawal on [3H]SCH23390 binding to rat striatal membranes

E Gili-MartínP Calvo


The effects of chronic ethanol administration and ethanol withdrawal on the kinetic and pharmacological properties of [3H]SCH23390 binding sites and the labelling of central dopamine D-1 receptors were studied in the striatum of the rat. Chronic 40 day ethanol treatment produced a statistically significant decrease (p < 0.05) in maximum binding (Bmax) on striatal dopamine D-1 receptors of the rat, KD remaining unaltered. The withdrawal of ethanol did not affect the kinetic binding parameters. The rank order of potency in displacing the specific [3H]SCH23390 binding of several dopamine antagonists, agonists and serotonin-related drugs was consistent with the pharmacological profile of dopamine D-1 receptors. Chronic ethanol treatment led to a statistically significant increase in receptor affinity (lower Ki than controls) for (+)-butaclamol (p < 0.05). Ethanol withdrawal for 24 hr increased the affinity of [3H]SCH23390-labeled binding sites for norepinephrine. The addition of 0.03-0.68 M ethanol in vitro had no significant effects on [3H]SCH23390 binding in striatal preparations taken from both control and ethanol-treated rats. The results show that rat striatal [3H]SCH23390-labelled binding sites are affected by different condi...Continue Reading


May 1, 1992·Trends in Pharmacological Sciences·H H Samson, R A Harris
Jun 28, 1992·Annals of the New York Academy of Sciences·H H SamsonC W Hodge
May 1, 1992·Trends in Pharmacological Sciences·G F Koob
Jun 28, 1992·Annals of the New York Academy of Sciences·G F Koob
Jan 1, 1991·Trends in Pharmacological Sciences·R A Gonzales, P L Hoffman
Jan 1, 1991·Annals of the New York Academy of Sciences·F F WeightR W Peoples
May 1, 1990·Alcohol·G F Koob, F Weiss
Sep 1, 1990·Biochemical Pharmacology·E Gil MartinP Calvo Fernández
Jan 1, 1989·Life Sciences·J BillingsH F Kung
Jun 1, 1988·Journal of Neurochemistry·R E Hruska
Aug 1, 1983·Computer Programs in Biomedicine·G A McPherson
Sep 3, 1984·Life Sciences·M WaelbroeckJ Christophe
Apr 15, 1984·The Biochemical Journal·M WaelbroeckJ Christophe
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·J M WoodsM J Druse
Jan 1, 1988·Neurochemistry International·H OllatS Parvez
Jan 1, 1988·Neurochemistry International·K F Tipton

❮ Previous
Next ❯


Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E Gil-MartínA Fernández-Briera
Apr 25, 2001·Kidney International·M A Vieira-CoelhoP Soares-da-Silva
Apr 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S M M VasconcelosG S B Viana
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P GomesP Soares-Da-Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.