Effects of chronic exposure to anaesthetic gases on some immune parameters

The Science of the Total Environment
A BargelliniP Borella

Abstract

A cross-sectional survey was carried out to evaluate the relation between occupational exposure to low levels of anaesthetic gases (nitrous oxide and isoflurane) and immune parameters. Fifty-one anaesthetists were recruited among different Services of Anaesthesiology and Reanimation. The control group consisted of non-exposed physicians, similar for gender, age, and job grade. Total number of lymphocytes, lymphocyte subpopulations and the natural killer (NK) cytotoxic activity were measured. Information on personal and professional characteristics and on short- and long-term exposure was collected. Percentages of T cells (CD3) decreased significantly in anaesthetists compared to controls, whereas numbers of NK cells (CD16+ CD3-) increased. After correction for confounders, short-term (last 2 weeks) exposure was associated with a decrease in percentages of total T and T helper (CD4) cells. Furthermore, T helper percentages were significantly reduced with increasing individual exposure score evaluated on the basis of working days and levels of anaesthetic gases in operating rooms. A significant X-ray-associated increase of numbers and percentages of NK cells was lastly observed. Despite limited present exposure to anaesthetic gas...Continue Reading

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Citations

May 3, 2005·International Archives of Occupational and Environmental Health·Antonio AccorsiFrancesco Saverio Violante
Jun 27, 2009·Journal of Environmental Monitoring : JEM·Lurdes I B SilvaA C Duarte
Feb 11, 2005·Journal of the American Veterinary Medical Association·Jean-Jacques Kona-BounEric Troncy
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Jul 11, 2008·Expert Opinion on Drug Safety·V FodaleLb Santamaria
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Jun 11, 2016·Anesthesiology·Lindsay M StollingsYan Xu
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Mar 7, 2020·Immunopharmacology and Immunotoxicology·Monireh MohsenzadeganShahnam Sedigh Maroufi
Nov 3, 2020·Anesthesiology and Pain Medicine·Abdollah JafarzadehReza Vazirinejad
Feb 23, 2021·Journal of Immunotoxicology·Ashraf Mahmoud EmaraRehab Mohamed Elgharabawy

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