Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels

British Journal of Pharmacology
A De LucaD Conte Camerino

Abstract

1. The effects of a 4-month daily treatment with recombinant human growth hormone (GH) (150 micrograms kg-1) to aged rats were evaluated on the passive and active membrane electrical properties of extensor digitorum longus (EDL) muscle fibres in vitro by means of a two intracellular microelectrode technique. 2. Chronic GH treatment completely restored the diameter and the membrane capacitance of aged EDL muscle fibres and significantly lowered the membrane resistance towards the adult value. There was also an increase of the threshold current, a shortening of the latency and an increase of the amplitude of the action potential and a significant amelioration of the membrane firing capability. 3. The effects were almost fully attributable to a significant 50% increase of resting conductance to chloride ions (GCl), although an observed restoration of potassium conductance and a possible effect on voltage-activated sodium channels could contribute to the effects. 4. EDL muscle fibres of untreated aged rats showed a different pharmacological response to 2-(p-chlorophenoxy) propionic acid (CPP) enantiomers from that seen in adult rats; the S-(-) isomer was less potent in blocking GCl and the R-(+) isomer always increased GCl instead ...Continue Reading

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Citations

Feb 7, 2002·Experimental Gerontology·Eli CarmeliAbraham Z Reznick
Feb 22, 2012·PloS One·Juan Del CosoJesús Muñoz-Guerra
May 4, 2020·Pflügers Archiv : European journal of physiology·Concetta AltamuraPaola Imbrici
Aug 9, 2001·Neurobiology of Disease·J R Singleton, E L Feldman

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