Abstract
Rats received daily injections of haloperidol (HAL, 5 mg/kg SC, or IP) or tartaric acid vehicle for 14-21 days. Four to six days after discontinuation of the daily injections, rats were given a single 5-min tail pinch (TP) test. HAL-treated rats showed significantly shorter latencies to display oral behaviours (OB: licking, gnawing, or drinking) compared to controls in five separate replications. Food consumption per se was not consistently affected. Shorter OB latencies were significantly correlated both with increased striatal 3H-spiperone binding and with apomorphine stereotypy scores. In a final experiment, this effect of HAL on OB latencies was blocked by a systemic injection of naloxone (2 mg/kg IP) prior to the TP test. Naloxone did not affect OB latency in control rats, suggesting the possibility of endogenous opiate involvement in the chronic HAL effects. The overall results suggest that OB latencies following mildly activating stimulation may provide a useful behavioural assay for neuroleptic-induced oral abnormalities as well as a functional index of striatal dopamine D-2 receptor sensitivity.
References
Aug 15, 1979·European Journal of Pharmacology·A ClowC D Marsden
Nov 24, 1976·Psychopharmacology·L M Gunne, S Bárány
Dec 5, 1975·Brain Research·S M AntelmanA E Fisher
Oct 1, 1986·Biological Psychiatry·L H TecottS J Peroutka
Jan 1, 1985·Journal of Neural Transmission·N M RupniakC D Marsden
Jul 17, 1985·European Journal of Pharmacology·R G MacKenzie, M J Zigmond
Jan 1, 1987·Psychopharmacology·G EllisonJ Kinney
Sep 21, 1987·Life Sciences·A D LevyG D Ellison
Jul 1, 1987·Neuropharmacology·P Jenner, C D Marsden
Sep 1, 1988·Survey of Ophthalmology·J A Khan, D M Albert
Jan 1, 1988·Psychopharmacology·R E SeeG D Ellison
Jan 1, 1988·Life Sciences·P M CarveyH L Klawans
Mar 17, 1987·European Journal of Pharmacology·J R Martin, A E Takemori
Dec 1, 1986·Pharmacology, Biochemistry, and Behavior·L A RodriguezM L Camarena
Feb 1, 1985·Neuropeptides·D BlancL E Eiden
Apr 29, 1983·Science·J L WaddingtonR C Bourne
Oct 1, 1983·Biochemical Pharmacology·S FlemingerC D Marsden
Jan 1, 1983·Clinical Neuropharmacology·D Tarsy
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F TangJ P Schwartz
Jan 1, 1984·Psychopharmacology·N M RupniakC D Marsden
Sep 1, 1984·Biological Psychology·J G O'Gorman
Apr 23, 1984·Brain Research·S CabibA Oliverio
Oct 1, 1984·Life Sciences·J G CsernanskyL E Hollister
Jan 1, 1982·Psychopharmacology·T F SeegerE L Gardner
Citations
Jan 1, 1993·Psychopharmacology·R E SteinpreisJ D Salamone
Jun 8, 2013·Psychopharmacology·Jozsef HallerLeigh V Panlilio
Apr 1, 1995·Biological Psychiatry·D Denney, J R Stevens
Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·J Pollock, C Kornetsky
Oct 15, 1993·Brain Research. Developmental Brain Research·B K Lipska, D R Weinberger
May 30, 2002·Neuroscience and Biobehavioral Reviews·Peter TurroneJosé N Nobrega
Feb 1, 2003·Neuroscience·S SamarghandianT Shibasaki
Sep 29, 2004·Synapse·Raina M RogozaRam K Mishra